UNeMed wraps up 2018 Boot Camp

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OMAHA, Neb. (August 27, 2018)—UNeMed recently completed its fourth annual Technology Transfer Boot Camp, drilling nine students on technology transfer basics, invention disclosure evaluations, intellectual property law, technology marketing, contract negotiation and entrepreneurship.

As part of their project work, the students engaged in interactive team-based activities evaluating real inventions, developing a marketing strategy, drafting confidential and non-confidential invention summaries and participating in mock licensing deal negotiations.

The boot camp provides an avenue for students who are unable to intern at UNeMed, to learn about the commercialization process and equips them with skills that would allow them to seek out alternative careers after graduation.

“This is part of our overall educational mission, and fostering a culture of innovation and entrepreneurship at the University,” said Boot Camp director, Catherine Murari-Kanti, PhD “We hope these skills will prepare these scientists of tomorrow to remain on the cutting edge of innovative research.”

Each year, UNeMed recruits about 10 students for the boot camp, which is open to all University of Nebraska students. Boot Camp in 2018 was held Aug. 6-10.

From left are (front) Sruti Prathivadhi-Bhay, Jhonnette Shockley, Freshta Baher, Qin-Yin-Shi (Diana), PhD; (back) Arash Gonabadi, PhD, Devin DeLuna, Mitchell Milanuk, Nicholas Wojtynek, Deep Bhattacharya

 

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Venture capital forum returns to UNO

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OMAHA, Nebraska (August 27, 2018)—The University of Nebraska and Pipeline Entrepreneurs, a regional entrepreneurial organization, are again offering the public a rare opportunity to peek inside the mind of venture capitalists next month.

James Linder, M.D., delivered the keynote address at UNeMed’s 11th annual Research Innovation Awards Banquet on Oct. 26, 2017. Dr. Linder is CEO at Nebraska Medicine, the former President and CEO of UNeMed, and served as Interim President of the University in 2014.

Set for Tuesday, Sept. 11, “Confessions of a Venture Capitalist” will feature a moderated and open conversation that should reveal all that seasoned investors seek in small businesses and startups.

The event will be in the Mammel Hall Auditorium at the University of Nebraska at Omaha at 6 p.m. Refreshments and light snacks will be provided.

James Linder, M.D., Nebraska Medicine CEO and former interim President of the University of Nebraska, will moderate the discussion.

“I am extraordinarily pleased that we can again host this program through the partnership of NU with Pipeline,” Linder said. “It’s a wonderful opportunity for Nebraska students and local entrepreneurs to get insights into the securing of angel and venture funding. We are grateful that Tom is sharing experience that may ultimately help grow our local economy.”

The event will feature Pipeline mentor Tom Parkinson. Pipeline is an entrepreneurial fellowship that focuses on nurturing Nebraska, Kansas and Missouri entrepreneurs and their businesses.

Parkinson is Senior Director of IllinoisVENTURES, and has been investing in, mentoring and advising technology-based startup companies for more than 30 years. He was a partner with Woodland Venture Management in Chicago where he helped raise and manage two venture capital funds. Prior to that, he was the Executive Director of a successful seed capital fund affiliated with Northwestern University and the CFO of an award-winning technology business incubator.

“Confessions of a Venture Capitalist” is sponsored by UNO’s Center for Innovation, Entrepreneurship and Franchising and UNeMed, the technology transfer and commercialization office for UNMC and UNO.

The event is free and open to all. To RSVP, go to VCConfessions.eventbrite.com.

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Podcast: Science is even harder than you think

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Podcast: Science is even harder than you think

OMAHA, Neb. (Aug. 27, 2018)—UNeMed’s tech transfer podcast, “Innovation Overground,” published this morning its latest episode, “Fourth time’s the charm.”

In the latest episode, Overground hosts Joe Runge, Tyler Scherr and Charlie Litton, discuss the difficulty of reproducing results, especially in biological research. The crew also talks about those technologies that can be reliably reproduced in multiple labs…and why that’s sometimes still not enough.

The episode also featured antimicrobial peptides.

Innovation Overground was created to help promote academic innovation and the technology transfer and commercialization efforts at the University of Nebraska and beyond. The podcast intends to examine what it takes to advance academic inventions and discoveries beyond the research bench and into people’s lives as “actual things on a shelf.”

New episodes are published on Mondays, and are available on most podcast channels, including Google Play Music, iTunes, iHeartMusic, Podomatic, Spotify and Spreaker.

Use the below links to subscribe, listen to previous episodes and learn more.

Listen on Apple Podcasts
Listen on Google Play Music
Listen on iHeart Radio
Innovation Overground on Spotify
Listen to this podcast on Spreaker
Player FM
Pocket Cast
Luminary
 

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Nebraska joins Midwest partnering group for entrepreneurs, startups

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OMAHA, Neb. (Aug. 22, 2018)—The University of Nebraska is joining a regional partnering platform that hopes to link Nebraska innovations and startups with seasoned entrepreneurs and executives. UNeMed, the technology transfer and commercialization office for UNMC and UNO, will use the platform to help advance startups that began as Nebraska innovations and discoveries.

The platform is called the Midwest Executives-on-Roster or Midwest XOR for short. The University of Kentucky led in the creation of the platform.

Midwest XOR is a collaboration between regionally-partnered Midwest universities to broaden access to experienced entrepreneurial talent and facilitate matching of that talent to university-affiliated startups in need of executive management.

“Having access to broad range of entrepreneurs gives us an advantage,” UNeMed president and CEO Michael Dixon said. “And when it comes to advancing technologies that stand to improve the lives of people everywhere—not to mention the local economic impact—we’re going to take every advantage we can get.”

Every participating university has a research scope that is broader than its immediately accessible entrepreneur talent network, and there exists a need to better match university startup companies not just with talent, but with talent having experience and relationships in different industries. By combining the entrepreneur talent networks of all participating universities, startup companies can access a larger talent pool and have a greater chance of finding fundable executive management and ultimately succeeding. Similarly, Midwest XOR entrepreneurs that may be looking for their next move will now have an opportunity to review a larger pipeline of opportunities in a central and user-friendly space.

More than 70 select entrepreneurs will have access to the platform, and can search through the profiles of more than 50 initial university startups in the system. Additional interested entrepreneurs may access the platform through an application and qualification process. The University of Nebraska is joined on the platform by the following universities: Indiana University, Notre Dame University, Ohio State University, Ohio University, Oklahoma University, University of Chicago, University of Cincinnati, University of Louisville and University of Minnesota.For more information about the Midwest XOR, please contact midwestxor@uky.edu or visit https://www.research.uky.edu/office-technology-commercialization/executives-roster-xor.

 

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UNeMed podcast takes on baby steps of innovation

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OMAHA, Neb. (Aug. 20, 2018)—UNeMed’s tech transfer podcast, “Innovation Overground,” published this morning its latest episode, “Why hasn’t anyone invented this before?”

In the latest episode, Overground hosts Joe Runge, Tyler Scherr and Charlie Litton, discuss how applied 3D printing makes small, iterative inventions much more feasible. The crew also talks about “cramming needles and hooks into the eyes of children and other fun stuff” during the 17-minute episode.

The episode featured a UNMC invention, the “Suh Precision Syringe.”

Innovation Overground was created to help promote academic innovation and the technology transfer and commercialization efforts at the University of Nebraska and beyond. The podcast intends to examine what it takes to advance academic inventions and discoveries beyond the research bench and into people’s lives as “actual things on a shelf.”

New episodes are published on Mondays, and are available on most podcast channels, including Google Play Music, iTunes, iHeartMusic, Podomatic, Spotify and Spreaker.

Use the below links to subscribe, listen to previous episodes and learn more.

Listen on Apple Podcasts
Listen on Google Play Music
Listen on iHeart Radio
Innovation Overground on Spotify
Listen to this podcast on Spreaker
Player FM
Pocket Cast
Luminary

 

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Innovation Overground publishes new episode

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OMAHA, Neb. (August 13, 2018)—UNeMed’s tech transfer podcast, “Innovation Overground,” published this morning its latest episode, “A fistful of yardsticks.”

In the latest episode, Overground hosts Joe Runge, Tyler Scherr and Charlie Litton, discuss an inventor’s need to sometimes “innovate to innovate.” Overground crew explains that medical innovations sometimes require new measurements and models just to get to the big idea.

The episode also features a new approach to an old procedure for kidney failure, the AV fistula.

Innovation Overground was created to help promote academic innovation and the technology transfer and commercialization efforts at the University of Nebraska and beyond. The podcast intends to examine what it takes to advance academic inventions and discoveries beyond the research bench and into people’s lives as “actual things on a shelf.”

New episodes are published on Mondays, and are available on most podcast channels, including Google Play Music, iTunes, iHeartMusic, Podomatic, Spotify and Spreaker.

Use the below links to subscribe, listen to previous episodes and learn more.

Listen on Apple Podcasts
Listen on Google Play Music
Listen on iHeart Radio
Innovation Overground on Spotify
Listen to this podcast on Spreaker
Player FM
Pocket Cast
Luminary

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Innovation Overground takes on CRISPR in latest episode

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OMAHA, Neb. (August 6, 2018)—UNeMed’s tech transfer podcast, “Innovation Overground,” published this morning its latest episode, “The CRISPR episode.”

In the latest episode, Overground hosts Joe Runge, Tyler Scherr and Charlie Litton, discuss a gene editing tool, CRISPR, its popularity within science fiction and its practical uses out here in reality. The Overground crew talks about what CRISPR is, what it can and can’t do, and have some fun with rampaging mutants and superheroes.

The episode also features Easi-CRISPR a tool jointly invented at UNMC and the University of Tokai. The crew discusses how Easi-CRISPR makes genome editing remarkably better.

Innovation Overground was created to help promote academic innovation and the technology transfer and commercialization efforts at the University of Nebraska and beyond. The podcast intends to examine what it takes to advance academic inventions and discoveries beyond the research bench and into people’s lives as “actual things on a shelf.”

New episodes are published on Mondays, and are available on most podcast channels, including Google Play Music, iTunes, iHeartMusic, Podomatic, Spotify and Spreaker.

Use the below links to subscribe, listen to previous episodes and learn more.

Listen on Apple Podcasts
Listen on Google Play Music
Listen on iHeart Radio
Innovation Overground on Spotify
Listen to this podcast on Spreaker
Player FM
Pocket Cast
Luminary

 

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UNMC tops $135 million in research funding, sets new record

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University of Nebraska Medical Center researchers have set a new record – bringing in $135.6 million in research funding for fiscal year 2018, up 15.8 percent from $117 million the previous year.

Vice Chancellor Larsen

Vice Chancellor Larsen

“Kudos to our research community for their success and hard work,” said Jennifer Larsen, M.D., vice chancellor for research at UNMC. “Everyone contributed to this accomplishment. We have recruited and mentored outstanding faculty, successfully competed for large grant awards, and many people – from administrators to research technicians and coordinators – have worked hard alongside the investigators to make this happen.”

Dr. Larsen said UNMC saw increases in the total number of grants, the number of unique principal investigators, the total number of faculty on grants, the average size of grants, and the number of large grants such as center grants.

UNMC Chancellor Jeffrey P. Gold, M.D., said, “The research programs at UNMC are critical to our mission and serve as a key foundation to our definition of being a world-class academic medical center.

“This continued record-breaking research funding recognizes the excellence of our scientists, our facilities and the continued relevance of our research programs. Congratulations on another remarkable year.”

The following units saw double digit increases in their research awards: the Eppley Institute for Cancer Research (19.5 percent), the Munroe-Meyer Institute (39.3 percent), and the Colleges of Medicine (11.4 percent), Pharmacy (10.7 percent), and Public Health (63.4 percent).

Awards from federal agencies increased 15 percent overall, either as primary awards (11.8 percent; 90 percent of which came from the National Institutes of Health); or sub-awards, which include federal awards from other universities, the University of Nebraska (21 percent) or others (12 percent). U.S. Department of Defense awards through the National Strategic Research Institute increased 43 percent.

Regardless of the funding source, the $135.6 million is awarded to specific individuals for projects that cover a broad range of topics, including:

  • $2.27 million to Rob Lewis, PhD, Eppley Institute, to develop the Nebraska Center for Molecular Target Discovery & Development, which is focused on taking small molecules into new biomarkers or treatments for cancer and other diseases.
  • $2.1 million to Keely Buesing, M.D., department of surgery, for novel strategies to address en route care of warfighters who sustain lung injury.
  • $1.64 million to Surinder Batra, PhD, College of Medicine, for a multi-project grant focused on understanding pancreatic cancer metastasis.
  • $1.14 million to Tatiana Bronich, PhD, College of Pharmacy, to continue to grow and develop the Nebraska Center for Nanomedicine, strategies to transform medicines to make them more effective in reaching their target.
  • $510,000 to David Dzewaltowski, PhD, College of Public Health, for community strategies that might improve the physical activity of youth.
  • $380,000 to Christine Eisenhauer, PhD, College of Nursing-Northern Division, for a mobile technology strategy to engage rural men in losing weight.

 

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Innovation Overground podcast airs next episode

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OMAHA, Neb. (July 30, 2018)—UNeMed’s tech transfer podcast, “Innovation Overground,” published this morning its latest episode, “Tech transfer 101 & leadership.”

In the latest episode, Overground hosts Joe Runge, Tyler Scherr and Charlie Litton, discuss some behind the scene basics of technology transfer and commercialization. The crew also banters about leadership as they poke a little fun at themselves in a light-hearted 19-minute episode.

The episode also featured two UNMC innovations, including NeuroFreeze and UNeMed’s Salesforce implementation.

Innovation Overground was created to help promote academic innovation and the technology transfer and commercialization efforts at the University of Nebraska and beyond. The podcast intends to examine what it takes to advance academic inventions and discoveries beyond the research bench and into people’s lives as “actual things on a shelf.”

New episodes are published on Mondays, and are available on iTunes, Google Play Music, and Spreaker. It will soon be available on Spotify and iHeartMusic.

Current subscription options for the Innovation Overground podcast:

Listen on Apple Podcasts
Listen on Google Play Music
Listen on iHeart Radio
Innovation Overground on Spotify
Listen to this podcast on Spreaker
Player FM
Pocket Cast
Luminary

 

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UNMC solves big data problem in EHRs

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OMAHA, Neb. (July 24, 2018)—A modern genetic test for a cancer patient contains more information than ever before: Too much, in fact, for modern digital medical records.

That’s a problem. A big, big data problem. But it’s a problem with a solution at the University of Nebraska Medical Center.

New tests, particularly those genetic cancer tests, hold critical clues about the nature and ferocity of a tumor. They help doctors and patients plan treatments, and adjust for new mutations in the tumor.

But those tests don’t neatly fit into modern health records. In fact, those test results don’t fit at all. Physicians must wade through multiple file attachments, or scroll through an apparently never-ending “notes” section for the important details.

It’s like looking for a specific movie scene among a stack of old VHS tapes. That’s great for 1995, but not in today’s digital age that moves at warp speed.

The problem is that electronic health records—EHR for short—were originally created to help the billing process.

“EHRs were not built for clinical teams to use as searchable databases,” said Kelly Choi, M.D., GenomOncology’s Chief Commercial Officer. GenomOncology is a Cleveland-based firm focused specifically on all that biomedical data, or informatics that comes out of cancer gene testing and research.

GenomOncology builds powerful engines that doctors and researchers use to tease important information from things like complex genetic tests. After signing an exclusive agreement with UNMC, GenomOncology now has a way to transmit those results to a patient’s EHR, arming their doctors and care-providers with a clearer picture of their patient’s health and history.

“Most in the industry thought it wasn’t possible to pass genomic data in a discrete manner with the current infrastructure, but we were able to find a way, with the team at UNMC,” said Manuel Glynias, founder and CEO of GenomOncology.

Dr. James Campbell

The deal began with UNMC researchers Scott Campbell, PhD, and Jim Campbell, M.D., who managed to simplify the complex. They developed a way to codify and name the multitude of facts that come from cancer gene testing. It needed to be something that a doctor could quickly and easily understand.

“There’s all this new research about cancer, and none of it matters until you can determine what kind of cancer you have and what to do about it,” said Joe Runge, the business development manager at UNMC’s technology transfer and commercialization office, UNeMed. “This technology helps doctors more easily integrate all this new information.”

UNeMed, negotiated the licensing agreement, which pairs GenomOncology’s powerful engine with the Campbells’ elegant system. The system is called the Nebraska Lexicon Synoptic Pathology Reporting Module, and functions as an add-on to the most widely-used EHR terminology in the world, SNOMED CT.

“This doesn’t happen without Scott Campbell and Jim Campbell,” said Catherine Murari-Kanti, a licensing specialist at UNeMed. “But they can’t do this without GenomOnocolgy’s platform. It’s the perfect marriage.”

Dr. Scott Campbell

Dr. Scott Campbell

GenomOncology’s platform, now armed with the UNMC module, will do more than just help with diagnoses treatment plans. The system could make a dramatic impact in research, helping filter and enroll patients for clinical trials.

“There’s a lot of cool stuff going on in oncology, and I think we’re underserving the patient because we can’t identify potential patients for trials and vice versa,” Choi said.

By making the EHR a more useful database, researchers and clinicians can find potential patients or trial programs. They will no longer need to spend countless hours poring through attachment files.

“Less than 5 percent of cancer patients get enrolled in clinical trials,” Choi said. “That number hasn’t changed since the 1980s in part due to various informatics challenges. We can do a lot better than that.”

GenomOncology enables the application of genomics in oncology to improve patient care. We have applied our expertise in genomics, technology and data integration to create solutions for cancer care providers. Our solutions are end-to-end: from the data coming out of the sequencer to the bedside where oncologists make treatment decisions. Our technology streamlines workflow and creates actionable reports for pathologists. Downstream, we integrate molecular and clinical information, providing oncologists with powerful decision-support tools that enable treatment selection, patient identification for clinical trials, and a “patients-like-mine” feature for use in difficult cases – all delivered through a real-time platform. Our solutions also enable “Big Data” analysis of aggregate data to drive research and new insights.

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UNeMed hosting regional drug development conference

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OMAHA, Neb. (July 25, 2018)—A new conference will bring together about a dozen Midwestern universities with major pharmaceutical firms as a way to promote early-stage medical technologies, officials announced today.

The event is called the Midwest Drug Development Conference, and is hosted by the University of Nebraska Medical Center’s technology transfer and commercialization office, UNeMed.

The primary goal of the event is to create one event where pharmaceutical firms and investor groups can learn about the latest therapeutic technologies and startup companies. The conference is exclusively aimed at Midwestern universities, but the industrial and investors groups could span the globe.

“I really dislike the term ‘flyover country,’ but there’s no escaping that perception,” UNeMed president and CEO Michael Dixon said. “We have a ton of research talent and innovation at Nebraska, and so do our friends across the region. Putting us all under one roof gives those companies a good reason to get on a plane to see what they’re missing.”

A closer look at the 13 participating universities shows that they collectively accounted for $4.76 billion in research, produced $71.4 million in revenues for their universities, disclosed 1,783 new inventions, created 85 new startup companies, and produced 36 new products in 2016 alone.

Planners hope to build on the region’s activity, and create more opportunities for academic medical researchers. The aim is then translating those opportunities into collaborative partnerships that move innovations and discoveries into further development.

So far, the list of participating universities include Nebraska, Kansas, Kansas State, Iowa, Iowa State, Indiana, Missouri, Notre Dame, Purdue, Washington University in St. Louis, Colorado State, Oklahoma and Kentucky.

The conference will feature more than 50 presentations of Midwestern universities’ early- and middle-stage technologies and startups. The 10-minutes presentations will cover a wide scope of conditions and diseases, including cancer, infectious diseases and central nervous disorders, to name a few.

The Midwest Drug Development Conference will be held on Oct. 1-2, 2018 in the Omaha Marriott Capitol District.

Register at www.midwestdrugdevelopment.com/tickets. Through a generous sponsor, a limited number of registration fees will be waived for potential investors and biotech and pharmaceutical company representatives. Contact UNeMed to learn how to receive a waiver code.

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UNeMed launches tech transfer podcast

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OMAHA, Neb. (July 23, 2018)—UNeMed launched today its pilot episode of a planned podcast series, “Innovation Overground,” which will publish new episodes on Mondays.

The series was created to help promote academic innovation and the technology transfer and commercialization efforts at the University of Nebraska. The podcast intends to examine what it takes to advance academic inventions and discoveries beyond the research bench and into people’s lives as “actual things on a shelf.”

Listen on Apple Podcasts“We really want to tell the untold stories of innovation,” said Joe Runge, one of the podcasts’ three co-hosts and UNeMed’s Business Development Manager. “We see these stories every day, and they’re a really interesting and fun way to show people how universities—not just Nebraska—are working to improve our lives.”

Listen on Google Play MusicRunge is joined on the podcast by UNeMed licensing associate Tyler Scherr, PhD, and communications specialist Charlie Litton. The podcast is currently available on iTunes and Google Play Music. The podcast will eventually appear on Spotify after the third episode and on iHeartRadio after the fifth episode.

In the first episode, which runs about 17 minutes, the co-hosts banter about some of the more pervasive “myths” associated with tech transfer. They also discuss the idea of moving publicly funded research into things on a shelf, and point out that innovation doesn’t have to be a big idea to make a life-altering impact.

“I think what’s great about this project are the fun little nuggets we find about the innovations we discuss,” said Scherr. “This isn’t going to be a weekly innovation infomercial. Our goal here is to make these podcasts less ‘ShamWow!’ and more VH-1’s ‘Behind the Music.'”

All podcasts are expected to run about 15 minutes, and the hosts said they plan to discuss more than just Nebraska innovations. Initial podcasts, however, will discuss UNMC and UNO innovations, including Easi-CRISPR and Avert’s concussion device.

“We could make this about just Nebraska or UNMC or even just UNeMed,” Runge said. “But then that wouldn’t be very interesting to very many people. What is interesting is finding those stories and telling them in a compelling way. Plus, it helps us get Charlie out of the office.”

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NIH SBIR/STTR proposal workshop coming to UNMC

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The Nebraska Business Development Center is offering a workshop to help UNMC researchers “prepare a compelling proposal” for the National Institutes of Health’s Small Business Innovation Research and Small Business Technology Transfer grants.

The two-day workshop will be in room 1005 of the Durham Research Center beginning at 8 a.m. on July 25. The workshop concludes on July 26, and cost is $45. Purchase tickets and learn more here.

Attendees can expect to learn:

  • Current information on the SBIR/STTR program
  • Strategies for targeting proposals to meet the mission and requirements of NIH
  • Step-by-step instruction on how to write each section of a proposal
  • Elements of a successful commercialization plan
  • How to meet the reviewers’ expectations
  • Navigating the process of submission
  • Common problems and pitfalls, and how to avoid them

The workshop will be presented by Shannon Bass, a professional consultant with BBC Entrepreneurial Training and Consulting. According to its website, BBCetc is Michigan-based consulting firm that advises “clients in the areas of funding eligibility and proposal development, commercialization and business planning, and grant and contract management.”

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UNMC scientists play key role in significant cancer breakthrough

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Genome-editing technology could reprogram T cells to allow them to better fight cancer cells

by Tom O’Connor, UNMC

OMAHA, Neb. (July 12, 2018)—Two University of Nebraska Medical Center scientists and their novel Easi-CRISPR genome-editing technology have contributed to a significant breakthrough in the fight against cancer.

The discovery may lead to new and safer treatments for autoimmune and other diseases, including rare inherited disorders.

From left are Channabasavaiah Gurumurthy, PhD, and Rolen Quadros.

The two UNMC scientists – Channabasavaiah Gurumurthy, D.V.M., PhD, associate professor of developmental neuroscience at the Munroe-Meyer Institute, and Rolen Quadros, transgenic researcher in the Mouse Genome Engineering Core Facility – collaborated with researchers at the University of California, San Francisco (UCSF) to develop a technique in which they genetically reprogrammed T cells, the body’s foremost immune system fighter, to find and destroy cancer cells in mice.

The new method, described in the July 11 issue of Nature, offers a robust molecular “cut and paste” system to rewrite genome sequences in human T cells without using viruses to insert the DNA.

The collaboration began more than two years ago when Dr. Gurumurthy met Alex Marson, M.D., PhD, associate professor of microbiology and immunology, UCSF, and principal investigator of the study, at a scientific conference where they discussed the idea of using the Easi-CRISPR method to engineer T cells.

Theo Roth, a student pursing M.D. and PhD degrees in UCSF’s Medical Scientist Training Program and first author on the study, tested the idea and then did a series of other technical improvements to efficiently engineer T cells.

Before this breakthrough, numerous attempts by many researchers to place long sequences of DNA into T cells had not been effective. “The typical success rate of inserting longer DNA sequences into T cells is about one percent or less,” Dr. Gurumurthy said.

“Easi-CRISPR provided us one of the ways to develop an efficient strategy to insert longer DNA cassettes into T cells,” he said. “With this method, we can take a cancer patient’s blood cells, isolate the T lymphocytes, manipulate the genome and train them to kill cancer cells, then transfer them back into the patient. Engineering a patient’s own T cells to find and kill cancer cells would be the most effective way of treating cancer.”

T cells are naturally attracted to an antigen on the cancer cell surface. Genetic engineering turns those cells into super cancer cell killers.

To demonstrate the new method’s versatility and power, the researchers used it to repair a disease-causing genetic mutation in T cells from children with a rare genetic form of autoimmunity and also created customized T cells to seek out and kill human melanoma cells.

Viruses cause infections by injecting their own genetic material through cell membranes, and since the 1970s, scientists have exploited this capability, stripping viruses of infectious features and using the resulting “viral vectors” to transport DNA into cells for research, gene therapy and in a well-publicized recent example, to create the CAR T-cells used in cancer immunotherapy.

T cells engineered with viruses are now approved by the U.S. Food and Drug Administration to combat certain types of leukemia and lymphoma. But, creating viral vectors is a painstaking, expensive process, and a shortage of clinical-grade vectors has led to a manufacturing bottleneck for both gene therapies and cell-based therapies.

Even when available, viral vectors are far from ideal, because they insert genes haphazardly into cellular genomes, which can damage existing healthy genes or leave newly introduced genes ungoverned by the regulatory mechanisms that ensure that cells function normally.

These limitations, which could potentially lead to serious side effects, have been cause for concern in both gene therapy and cell therapies such as CAR T-based immunotherapy.

“There has been 30 years of work trying to get new genes into T cells,” Roth said. “Hundreds of labs can now engineer these cells. They can work with increasingly more complex DNA sequences and try more possibilities, which will significantly speed up the development of future generations of cell therapy.”

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Nebraska ranks among world’s top 100 in earning U.S. patents

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LINCOLN, Neb. (July 11, 2018)—A new report ranks the University of Nebraska among the top 100 universities worldwide in earning U.S. patents to protect innovative research and discoveries.

The report was released this summer by the National Academy of Inventors and the Intellectual Property Owners Association. It ranks Nebraska 70th globally for the number of U.S. patents awarded to NU’s technology transfer offices – NUtech Ventures at the University of Nebraska-Lincoln and UNeMed Corp. at the University of Nebraska Medical Center and the University of Nebraska at Omaha.

By earning patents, NUtech Ventures and UNeMed can work effectively with NU faculty, staff and students to bring research to the marketplace, resulting in local startup companies, new jobs and university-licensed products that grow the economy and improve quality of life in Nebraska and beyond.

Dr. Bounds

“To be named in the company of some of the world’s leading research universities is one more sign that the University of Nebraska is on a remarkable trajectory in growing our state for the future,” NU President Hank Bounds said. “The good work of our technology transfer offices is helping our talented faculty and students generate broad impact from their innovations – a benefit not just to our economy, but to the people whose lives are ultimately transformed by research born at the University of Nebraska.”

Bounds noted that the university represents a $3.9 billion annual economic engine for the state, generating 11,000 new graduates each year who meet critical workforce needs in agriculture, healthcare, teaching, business, STEM and other areas. NU research, which alone has an almost $400 million annual economic impact, also continues to earn recognition. An independent report last year ranked the University of Nebraska in the top 16 percent nationally for its success in commercializing faculty work in areas like agriculture, engineering and medicine for economic growth.

The new report’s rankings are based on 2017 patent data from the U.S. Patent and Trademark Office. Nebraska’s 37 patents include a robotic surgical device and a structural concrete formula to shield buildings from electromagnetic pulse attack.

After securing a patent, the university brings research to market by licensing technology to existing companies or university startup companies. Most university technology is considered early-stage and requires additional research and development.

For example, the structural concrete formula – developed by College of Engineering faculty Christopher Tuan and Lim Nguyen – is licensed to a U.S. company developing buildings that shield from electromagnetic pulses. The robotic surgical device is licensed to university startup company Virtual Incision Corp., led by UNL engineering professor Shane Farritor and UNMC surgeon Dmitry Oleynikov, with the goal of making surgeries more affordable and less invasive.

“We look forward to these newly patented technologies impacting society over the next several decades as they are commercialized,” said Brad Roth, executive director of NUtech Ventures. “Together with UNeMed, our offices are committed to protecting the University of Nebraska’s intellectual property as a critical step in moving innovations from the lab to the marketplace.”

UNeMed President and CEO Michael Dixon said: “The innovations described in these patents not only have the chance to significantly improve health care, but also form the backbone of the many new startup companies that create jobs and wealth at a local level.”

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Food for thought: UNO capstone program can drive UNMC innovations

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Sachin Pawaskar (left) and Thang Nguyen chat shortly before UNO’s IS&T Capstone presentation on June 1, 2018. The project was the realization of WeChart, Nguyen’s invention of a more efficient way to teach nursing students better clinical charting skills.

by Charlie Litton, UNeMed | June 18, 2018

Nourish an invention with a robust diet of diverse thoughts and competing ideas. Go ahead.

Maybe that sounds dangerous. But diversity of thought is a super-food for those delicate innovations as they embark on what will be an absolutely brutal journey.

It’s some tough love, to be sure, but do that and remarkable things can happen.

Maybe you would rather swaddle an idea in bubble wrap and wait for the phone to ring? There’s a word for that. It’s called neglect. All you’ll likely do then is watch that idea grow old, wither and die.

It happens. It doesn’t even have to be anyone’s fault, either. It’s just the dark side of innovation that happens everywhere. Sometimes there just isn’t enough oxygen to go around.

An ER nurse, Thang Nguyen, saw it happening to one of his ideas. As one of the more innovative people at the University of Nebraska Medical Center, most of his ideas come right out of the clinic. He has a long list of better, more efficient ways to do things like washing debris from wounds and helping patients breathe.

Just like any prolific inventor, Thang finds that sometimes those ideas work and sometimes they don’t. And, like too many clever ideas and better ways, sometimes they never get a real chance to fail or succeed.

One of Nguyen’s ideas—a software program to help nursing students learn the arcane art of charting patients in real time—was heading down a path toward obscurity.

Tapping new resources

Thang’s idea: A new way to train student nurses without risking patient safety or privacy. Medical schools don’t often have a lot of resources that involve advanced coding and application design.

Except, it turns out, they actually did: Right down the road at UNO’s Peter Kiewit Institute, a seven-minute drive with bad traffic. PKI is home to the University of Nebraska Omaha’s College of Information Science and Technology and the University of Nebraska-Lincoln’s College of Engineering.

“There’s a lot of talent here at PKI that no one at UNMC even knows about,” Nguyen said.

Creating that well-balanced meal of innovation super food is not that hard. It turns out, the first, most important step is just getting the right people in the same room. What Nguyen really needed wasn’t another person in healthcare. What he needed was someone completely removed from healthcare. He needed a software engineer.

They have those in spades at UNO’s College of Information and Science Technology, or IS&T for short. They also make some serious hay with a capstone program where IS&T grad students develop concepts and ideas into actual things. Working prototypes ready for full-scale testing and, in some cases, widespread use.

Nguyen’s idea, called WeChart, lay dormant for four years. Then it joined the capstone program.

Working with UNO, Nguyen said he got more “accomplished in one semester than we did in the previous four years.”

It took a full academic year and two teams of students, but Nguyen now has a final product that, once upon a time, only lived in his imagination. It now lives in the real world.

And it will be used in the real world. UNMC’s emergency medicine department will train their student nurses with it. If all goes well, we might see other teaching hospitals and medical schools adopt the charting training program.

That’s great. Wonderful, in fact.

The bigger picture

For my money, the University of Nebraska—and other similar institutions, if they’re paying attention—should be excited about a more important prototype. I’m talking about the relationship forged between two disparate departments and two wildly different campuses.

“Medical people think one way,” Nguyen said, “a software engineer thinks one way…We should not forget that we are there to solve one central problem even if there are multiple ways of looking at it.”

For Nguyen, the “problem” of the hour was too-common charting errors from inexperienced and poorly trained young nurses. His WeChart application is one solution. We’ll find out real soon if that solution works like we all hope it does.

But there are bigger problems. Unknown problems. Problems the University of Nebraska can identify and solve, if the right people can get together.

“Why can’t we be a powerhouse,” asked the capstone program leader, Sachin Pawaskar, PhD, a research technology fellow at IS&T. “I think we have that potential.”

Sachin Pawaskar, leader of UNO’s IS&T Capstone program, addresses the gathering following his team’s WeChart presentation on June 1, 2018.

Pawaskar, who also holds an MBA, made it clear the WeChart project was critically important for the capstone program. He wanted a “showcase of what a successful partnership and relationship could be.”

That showcase will be on full display on campus at UNMC in the coming semesters as young nursing students put WeChart through the paces.

Nguyen’s idea will finally get the chance to sink or swim on its own merits, which is all anyone can really ask.

But more than that, UNMC and UNO now have a buffet line that can fuel some innovative ideas across a treacherous divide—the chasm between the sketch of a promising concept and a final product that actually makes life better.

“I really think that the healthcare area is just set up for an IT revolution,” Pawaskar said shortly after his students presented their WeChat project to Nguyen and dozens of others. Pawaskar added: “I really feel that healthcare can be totally revolutionized if we can incorporate IT at the right places at the right levels…It’s not any silver bullet, but there’s so many things you can do.”

Nguyen nodded: “And the best part? All the pieces are already here.”

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