UNeMed hosting regional drug development conference

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OMAHA, Neb. (July 25, 2018)—A new conference will bring together about a dozen Midwestern universities with major pharmaceutical firms as a way to promote early-stage medical technologies, officials announced today.

The event is called the Midwest Drug Development Conference, and is hosted by the University of Nebraska Medical Center’s technology transfer and commercialization office, UNeMed.

The primary goal of the event is to create one event where pharmaceutical firms and investor groups can learn about the latest therapeutic technologies and startup companies. The conference is exclusively aimed at Midwestern universities, but the industrial and investors groups could span the globe.

“I really dislike the term ‘flyover country,’ but there’s no escaping that perception,” UNeMed president and CEO Michael Dixon said. “We have a ton of research talent and innovation at Nebraska, and so do our friends across the region. Putting us all under one roof gives those companies a good reason to get on a plane to see what they’re missing.”

A closer look at the 13 participating universities shows that they collectively accounted for $4.76 billion in research, produced $71.4 million in revenues for their universities, disclosed 1,783 new inventions, created 85 new startup companies, and produced 36 new products in 2016 alone.

Planners hope to build on the region’s activity, and create more opportunities for academic medical researchers. The aim is then translating those opportunities into collaborative partnerships that move innovations and discoveries into further development.

So far, the list of participating universities include Nebraska, Kansas, Kansas State, Iowa, Iowa State, Indiana, Missouri, Notre Dame, Purdue, Washington University in St. Louis, Colorado State, Oklahoma and Kentucky.

The conference will feature more than 50 presentations of Midwestern universities’ early- and middle-stage technologies and startups. The 10-minutes presentations will cover a wide scope of conditions and diseases, including cancer, infectious diseases and central nervous disorders, to name a few.

The Midwest Drug Development Conference will be held on Oct. 1-2, 2018 in the Omaha Marriott Capitol District.

Register at www.midwestdrugdevelopment.com/tickets. Through a generous sponsor, a limited number of registration fees will be waived for potential investors and biotech and pharmaceutical company representatives. Contact UNeMed to learn how to receive a waiver code.

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UNeMed launches tech transfer podcast

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OMAHA, Neb. (July 23, 2018)—UNeMed launched today its pilot episode of a planned podcast series, “Innovation Overground,” which will publish new episodes on Mondays.

The series was created to help promote academic innovation and the technology transfer and commercialization efforts at the University of Nebraska. The podcast intends to examine what it takes to advance academic inventions and discoveries beyond the research bench and into people’s lives as “actual things on a shelf.”

Listen on Apple Podcasts“We really want to tell the untold stories of innovation,” said Joe Runge, one of the podcasts’ three co-hosts and UNeMed’s Business Development Manager. “We see these stories every day, and they’re a really interesting and fun way to show people how universities—not just Nebraska—are working to improve our lives.”

Listen on Google Play MusicRunge is joined on the podcast by UNeMed licensing associate Tyler Scherr, PhD, and communications specialist Charlie Litton. The podcast is currently available on iTunes and Google Play Music. The podcast will eventually appear on Spotify after the third episode and on iHeartRadio after the fifth episode.

In the first episode, which runs about 17 minutes, the co-hosts banter about some of the more pervasive “myths” associated with tech transfer. They also discuss the idea of moving publicly funded research into things on a shelf, and point out that innovation doesn’t have to be a big idea to make a life-altering impact.

“I think what’s great about this project are the fun little nuggets we find about the innovations we discuss,” said Scherr. “This isn’t going to be a weekly innovation infomercial. Our goal here is to make these podcasts less ‘ShamWow!’ and more VH-1’s ‘Behind the Music.'”

All podcasts are expected to run about 15 minutes, and the hosts said they plan to discuss more than just Nebraska innovations. Initial podcasts, however, will discuss UNMC and UNO innovations, including Easi-CRISPR and Avert’s concussion device.

“We could make this about just Nebraska or UNMC or even just UNeMed,” Runge said. “But then that wouldn’t be very interesting to very many people. What is interesting is finding those stories and telling them in a compelling way. Plus, it helps us get Charlie out of the office.”

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NIH SBIR/STTR proposal workshop coming to UNMC

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The Nebraska Business Development Center is offering a workshop to help UNMC researchers “prepare a compelling proposal” for the National Institutes of Health’s Small Business Innovation Research and Small Business Technology Transfer grants.

The two-day workshop will be in room 1005 of the Durham Research Center beginning at 8 a.m. on July 25. The workshop concludes on July 26, and cost is $45. Purchase tickets and learn more here.

Attendees can expect to learn:

  • Current information on the SBIR/STTR program
  • Strategies for targeting proposals to meet the mission and requirements of NIH
  • Step-by-step instruction on how to write each section of a proposal
  • Elements of a successful commercialization plan
  • How to meet the reviewers’ expectations
  • Navigating the process of submission
  • Common problems and pitfalls, and how to avoid them

The workshop will be presented by Shannon Bass, a professional consultant with BBC Entrepreneurial Training and Consulting. According to its website, BBCetc is Michigan-based consulting firm that advises “clients in the areas of funding eligibility and proposal development, commercialization and business planning, and grant and contract management.”

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UNMC scientists play key role in significant cancer breakthrough

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Genome-editing technology could reprogram T cells to allow them to better fight cancer cells

by Tom O’Connor, UNMC

OMAHA, Neb. (July 12, 2018)—Two University of Nebraska Medical Center scientists and their novel Easi-CRISPR genome-editing technology have contributed to a significant breakthrough in the fight against cancer.

The discovery may lead to new and safer treatments for autoimmune and other diseases, including rare inherited disorders.

From left are Channabasavaiah Gurumurthy, PhD, and Rolen Quadros.

The two UNMC scientists – Channabasavaiah Gurumurthy, D.V.M., PhD, associate professor of developmental neuroscience at the Munroe-Meyer Institute, and Rolen Quadros, transgenic researcher in the Mouse Genome Engineering Core Facility – collaborated with researchers at the University of California, San Francisco (UCSF) to develop a technique in which they genetically reprogrammed T cells, the body’s foremost immune system fighter, to find and destroy cancer cells in mice.

The new method, described in the July 11 issue of Nature, offers a robust molecular “cut and paste” system to rewrite genome sequences in human T cells without using viruses to insert the DNA.

The collaboration began more than two years ago when Dr. Gurumurthy met Alex Marson, M.D., PhD, associate professor of microbiology and immunology, UCSF, and principal investigator of the study, at a scientific conference where they discussed the idea of using the Easi-CRISPR method to engineer T cells.

Theo Roth, a student pursing M.D. and PhD degrees in UCSF’s Medical Scientist Training Program and first author on the study, tested the idea and then did a series of other technical improvements to efficiently engineer T cells.

Before this breakthrough, numerous attempts by many researchers to place long sequences of DNA into T cells had not been effective. “The typical success rate of inserting longer DNA sequences into T cells is about one percent or less,” Dr. Gurumurthy said.

“Easi-CRISPR provided us one of the ways to develop an efficient strategy to insert longer DNA cassettes into T cells,” he said. “With this method, we can take a cancer patient’s blood cells, isolate the T lymphocytes, manipulate the genome and train them to kill cancer cells, then transfer them back into the patient. Engineering a patient’s own T cells to find and kill cancer cells would be the most effective way of treating cancer.”

T cells are naturally attracted to an antigen on the cancer cell surface. Genetic engineering turns those cells into super cancer cell killers.

To demonstrate the new method’s versatility and power, the researchers used it to repair a disease-causing genetic mutation in T cells from children with a rare genetic form of autoimmunity and also created customized T cells to seek out and kill human melanoma cells.

Viruses cause infections by injecting their own genetic material through cell membranes, and since the 1970s, scientists have exploited this capability, stripping viruses of infectious features and using the resulting “viral vectors” to transport DNA into cells for research, gene therapy and in a well-publicized recent example, to create the CAR T-cells used in cancer immunotherapy.

T cells engineered with viruses are now approved by the U.S. Food and Drug Administration to combat certain types of leukemia and lymphoma. But, creating viral vectors is a painstaking, expensive process, and a shortage of clinical-grade vectors has led to a manufacturing bottleneck for both gene therapies and cell-based therapies.

Even when available, viral vectors are far from ideal, because they insert genes haphazardly into cellular genomes, which can damage existing healthy genes or leave newly introduced genes ungoverned by the regulatory mechanisms that ensure that cells function normally.

These limitations, which could potentially lead to serious side effects, have been cause for concern in both gene therapy and cell therapies such as CAR T-based immunotherapy.

“There has been 30 years of work trying to get new genes into T cells,” Roth said. “Hundreds of labs can now engineer these cells. They can work with increasingly more complex DNA sequences and try more possibilities, which will significantly speed up the development of future generations of cell therapy.”

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Nebraska ranks among world’s top 100 in earning U.S. patents

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LINCOLN, Neb. (July 11, 2018)—A new report ranks the University of Nebraska among the top 100 universities worldwide in earning U.S. patents to protect innovative research and discoveries.

The report was released this summer by the National Academy of Inventors and the Intellectual Property Owners Association. It ranks Nebraska 70th globally for the number of U.S. patents awarded to NU’s technology transfer offices – NUtech Ventures at the University of Nebraska-Lincoln and UNeMed Corp. at the University of Nebraska Medical Center and the University of Nebraska at Omaha.

By earning patents, NUtech Ventures and UNeMed can work effectively with NU faculty, staff and students to bring research to the marketplace, resulting in local startup companies, new jobs and university-licensed products that grow the economy and improve quality of life in Nebraska and beyond.

Dr. Bounds

“To be named in the company of some of the world’s leading research universities is one more sign that the University of Nebraska is on a remarkable trajectory in growing our state for the future,” NU President Hank Bounds said. “The good work of our technology transfer offices is helping our talented faculty and students generate broad impact from their innovations – a benefit not just to our economy, but to the people whose lives are ultimately transformed by research born at the University of Nebraska.”

Bounds noted that the university represents a $3.9 billion annual economic engine for the state, generating 11,000 new graduates each year who meet critical workforce needs in agriculture, healthcare, teaching, business, STEM and other areas. NU research, which alone has an almost $400 million annual economic impact, also continues to earn recognition. An independent report last year ranked the University of Nebraska in the top 16 percent nationally for its success in commercializing faculty work in areas like agriculture, engineering and medicine for economic growth.

The new report’s rankings are based on 2017 patent data from the U.S. Patent and Trademark Office. Nebraska’s 37 patents include a robotic surgical device and a structural concrete formula to shield buildings from electromagnetic pulse attack.

After securing a patent, the university brings research to market by licensing technology to existing companies or university startup companies. Most university technology is considered early-stage and requires additional research and development.

For example, the structural concrete formula – developed by College of Engineering faculty Christopher Tuan and Lim Nguyen – is licensed to a U.S. company developing buildings that shield from electromagnetic pulses. The robotic surgical device is licensed to university startup company Virtual Incision Corp., led by UNL engineering professor Shane Farritor and UNMC surgeon Dmitry Oleynikov, with the goal of making surgeries more affordable and less invasive.

“We look forward to these newly patented technologies impacting society over the next several decades as they are commercialized,” said Brad Roth, executive director of NUtech Ventures. “Together with UNeMed, our offices are committed to protecting the University of Nebraska’s intellectual property as a critical step in moving innovations from the lab to the marketplace.”

UNeMed President and CEO Michael Dixon said: “The innovations described in these patents not only have the chance to significantly improve health care, but also form the backbone of the many new startup companies that create jobs and wealth at a local level.”

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Food for thought: UNO capstone program can drive UNMC innovations

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Sachin Pawaskar (left) and Thang Nguyen chat shortly before UNO’s IS&T Capstone presentation on June 1, 2018. The project was the realization of WeChart, Nguyen’s invention of a more efficient way to teach nursing students better clinical charting skills.

by Charlie Litton, UNeMed | June 18, 2018

Nourish an invention with a robust diet of diverse thoughts and competing ideas. Go ahead.

Maybe that sounds dangerous. But diversity of thought is a super-food for those delicate innovations as they embark on what will be an absolutely brutal journey.

It’s some tough love, to be sure, but do that and remarkable things can happen.

Maybe you would rather swaddle an idea in bubble wrap and wait for the phone to ring? There’s a word for that. It’s called neglect. All you’ll likely do then is watch that idea grow old, wither and die.

It happens. It doesn’t even have to be anyone’s fault, either. It’s just the dark side of innovation that happens everywhere. Sometimes there just isn’t enough oxygen to go around.

An ER nurse, Thang Nguyen, saw it happening to one of his ideas. As one of the more innovative people at the University of Nebraska Medical Center, most of his ideas come right out of the clinic. He has a long list of better, more efficient ways to do things like washing debris from wounds and helping patients breathe.

Just like any prolific inventor, Thang finds that sometimes those ideas work and sometimes they don’t. And, like too many clever ideas and better ways, sometimes they never get a real chance to fail or succeed.

One of Nguyen’s ideas—a software program to help nursing students learn the arcane art of charting patients in real time—was heading down a path toward obscurity.

Tapping new resources

Thang’s idea: A new way to train student nurses without risking patient safety or privacy. Medical schools don’t often have a lot of resources that involve advanced coding and application design.

Except, it turns out, they actually did: Right down the road at UNO’s Peter Kiewit Institute, a seven-minute drive with bad traffic. PKI is home to the University of Nebraska Omaha’s College of Information Science and Technology and the University of Nebraska-Lincoln’s College of Engineering.

“There’s a lot of talent here at PKI that no one at UNMC even knows about,” Nguyen said.

Creating that well-balanced meal of innovation super food is not that hard. It turns out, the first, most important step is just getting the right people in the same room. What Nguyen really needed wasn’t another person in healthcare. What he needed was someone completely removed from healthcare. He needed a software engineer.

They have those in spades at UNO’s College of Information and Science Technology, or IS&T for short. They also make some serious hay with a capstone program where IS&T grad students develop concepts and ideas into actual things. Working prototypes ready for full-scale testing and, in some cases, widespread use.

Nguyen’s idea, called WeChart, lay dormant for four years. Then it joined the capstone program.

Working with UNO, Nguyen said he got more “accomplished in one semester than we did in the previous four years.”

It took a full academic year and two teams of students, but Nguyen now has a final product that, once upon a time, only lived in his imagination. It now lives in the real world.

And it will be used in the real world. UNMC’s emergency medicine department will train their student nurses with it. If all goes well, we might see other teaching hospitals and medical schools adopt the charting training program.

That’s great. Wonderful, in fact.

The bigger picture

For my money, the University of Nebraska—and other similar institutions, if they’re paying attention—should be excited about a more important prototype. I’m talking about the relationship forged between two disparate departments and two wildly different campuses.

“Medical people think one way,” Nguyen said, “a software engineer thinks one way…We should not forget that we are there to solve one central problem even if there are multiple ways of looking at it.”

For Nguyen, the “problem” of the hour was too-common charting errors from inexperienced and poorly trained young nurses. His WeChart application is one solution. We’ll find out real soon if that solution works like we all hope it does.

But there are bigger problems. Unknown problems. Problems the University of Nebraska can identify and solve, if the right people can get together.

“Why can’t we be a powerhouse,” asked the capstone program leader, Sachin Pawaskar, PhD, a research technology fellow at IS&T. “I think we have that potential.”

Sachin Pawaskar, leader of UNO’s IS&T Capstone program, addresses the gathering following his team’s WeChart presentation on June 1, 2018.

Pawaskar, who also holds an MBA, made it clear the WeChart project was critically important for the capstone program. He wanted a “showcase of what a successful partnership and relationship could be.”

That showcase will be on full display on campus at UNMC in the coming semesters as young nursing students put WeChart through the paces.

Nguyen’s idea will finally get the chance to sink or swim on its own merits, which is all anyone can really ask.

But more than that, UNMC and UNO now have a buffet line that can fuel some innovative ideas across a treacherous divide—the chasm between the sketch of a promising concept and a final product that actually makes life better.

“I really think that the healthcare area is just set up for an IT revolution,” Pawaskar said shortly after his students presented their WeChat project to Nguyen and dozens of others. Pawaskar added: “I really feel that healthcare can be totally revolutionized if we can incorporate IT at the right places at the right levels…It’s not any silver bullet, but there’s so many things you can do.”

Nguyen nodded: “And the best part? All the pieces are already here.”

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Scherr promoted to full-time licensing position

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Tyler ScherrOMAHA, Neb. (May 15, 2018)—Tyler Scherr, PhD, has been promoted from intern to a full-time licensing associate position with UNeMed, the technology transfer and commercialization office at the University of Nebraska Medical Center and the University of Nebraska at Omaha.

“We are incredibly fortunate to add the kind of rare skills and experience that Dr. Scherr brings to the team,” UNeMed president and CEO Michael Dixon said. “In addition to having a highly successful graduate research career, Dr. Scherr is an entrepreneur that understands the challenges and benefits of developing new ideas into products that can have a positive impact on healthcare.”

The promotion and full-time status expands his role of evaluating, marketing, and seeking partnerships for new inventions, cures, treatments and medical devices developed at UNMC and UNO. Dr. Scherr first joined UNeMed as a part-time intern in 2017.

UNeMed’s mission is to help UNMC and UNO researchers, faculty and staff move innovations and ground-breaking discoveries beyond the laboratory and into the marketplace. Dr. Scherr joins UNeMed’s talented stable of licensing experts who work every day to advance the University’s new discoveries into the future cures, treatments and products that might one-day affect millions around the world.

“The past year-and-a-half at UNeMed has been one of tremendous personal and professional growth,” Dr. Scherr said. “I’m deeply honored to accept this position, and I’m excited to continue working with UNMC’s and UNO’s gifted inventors and entrepreneurs.”

A native of Aberdeen, South Dakota, Dr. Scherr is the son of Dave Scherr and Liz Cox. He is a 2011 graduate of the University of Nebraska-Lincoln with an undergraduate degree in Biological Systems Engineering. Dr. Scherr received his doctorate in Biomedical Research from UNMC in December of 2016.

Dr. Scherr’s technology portfolio:

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Scherr, Zuniga featured in recent ‘Consider This’

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UNO researcher Jorge Zuniga, PhD—seen here during an Innovation Week event last October—holds up a cybernetic prosthetic hand, which he created almost entirely with 3D printers.

UNO researcher Jorge Zuniga, PhD—seen here during an Innovation Week event last October—holds up a cybernetic prosthetic hand, which he created almost entirely with 3D printers.

OMAHA, Neb. (April 17, 2018)—Tyler Scherr, PhD, a licensing associate at UNeMed, and Jorge Zuniga, PhD, a biomechanics expert at the University of Nebraska at Omaha’s biomechanics department, anchored a recent three-person panel on a local news program, “Consider This.”

The episode aired on Nebraska’s PBS affiliate, NET, and focused entirely on the marvels of 3D printing or additive manufacturing. The program covered a brief history of 3D printing and examined some of its wider applications before diving into current and even future applications.

Tyler Scherr, PhD

Dr. Scherr

Before joining UNeMed, Dr. Scherr played a large role in bringing 3D printing to the University of Nebraska Medical Center. While pursuing his doctorate in biomedical research, he co-founded UNMC’s 3D Maker’s Club.

Dr. Zuniga has gained international notoriety for his work creating affordable prosthetic limbs for children. His innovative use of 3D printing has made prosthetic devices accessible to countless children throughout the world. Much of his work is “open sourced” through his philanthropic project, Cyborg Beast. Many of his products—3D printing files—are largely available to anyone at little or no cost.

James Pierce, a graduate assistant in Dr. Zuniga’s lab, was also on the panel. Pierce is the co-founder of one of Omaha’s first 3D printing ventures, Kül 3D. Cathy Wyatt hosted the program.

“Consider This” is a half-hour weekly program produced by UNO Televeision and the UNO College of Communication, Fine Arts and Media.

Watch the entire episode here or follow this link: https://netnebraska.org/media/media.php?bin=NET&vidgroup=50005871

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Applications now open for 2018 Tech Transfer Boot Camp

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OMAHA, Neb. (May 9, 2018)—The 2018 Technology Transfer Boot Camp is scheduled for Aug. 6-10, UNeMed announced today.

Entering its fourth year, the Tech Transfer Boot Camp is aimed at scientists and students that are interested in what it takes to commercialize a new invention or discovery. The week-long event can also serve as fast-track toward an alternate career in science as a technology transfer professional.

The training program helps scientist gain a wide range of skills and experience that match their scientific knowledge and training.

The program will focus on several key areas relevant to a successful career in technology transfer, including:

  • Invention evaluation
  • Intellectual property law
  • Marketing and commercialization
  • Contract negotiation

UNeMed’s Tech Transfer Boot Camp will dive deeper than simple lectures. Topics wills be explored with hands-on activities meant to teach, correct and reinforce new skills and abilities.

Anyone within the University of Nebraska system is encouraged to apply and participate free of charge, but space is limited. People who aren’t affiliated with the University of Nebraska are also welcome, but will be charged $200 upon acceptance.

Applications will be accepted through Monday, July 30, and will be reviewed in the order they are received until all spaces are filled.

Use the embedded form below or apply here.

More information about the application process and requirements can be found at https://www.unemed.com/about-us/join-our-team#bootcamp.

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Taconic inks license deal for Easi-CRISPR

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Schematic of Easi-CRISPR

Schematic of Easi-CRISPR

RENSSELAER, N.Y. (April 23, 2018)—A technology developed in part at the University of Nebraska Medical Center was signed to a non-exclusive licensing deal that will bring Easi-CRISPR to the market.

Taconic Biosciences announced the agreement in a press release late last week, and indicated they would use the technology to genetically engineer mouse models for research purposes.

“Easi-CRISPR is the next progression of the revolutionary CRISPR/Cas technology,” John Crouse, vice president of scientific services for Taconic, said in the press release. “In an industry where time is a precious resource, access to this technology underscores Taconic’s commitment to providing our customers with the best solutions.”

The Easi-CRISPR technology could reduce research project timelines by six months, Crouse said.

A product of a collaboration between Channabasavaiah Gurumurthy, PhD, at UNMC and Masato Ohtsuka, PhD, at Tokai University in Japan, Easi-CRISPR dramatically improves the efficiency of genetic splicing. Recent headlines—and science-fiction plot lines—have featured CRISPR for is remarkable ability to precisely cut genetic code. What CRISPR cannot do very well, however, is insert or replace the genetic material.

Easi-CRISPR is that solution, providing research scientists the ability to produce genetically modified mice. That will help scientists better understand or possibly even better treat a multitude of diseases including various forms of cancer.

“The discovery of CRISPR hints at products and services that are now possible with Easi-CRISPR,” said Joe Runge, licensing specialist at UNeMed. “We’re over the moon that Taconic is the first of many to start making those possibilities real.”

Taconic is a fully-licensed provider of rodent model generation services and has over 20 years of model design experience. The company provides gene inactivation, gene mutation or replacement, transgene expression, RNAi, and gene editing via CRISPR/Cas9, pronuclear injection, and homologous recombination technologies.

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Free seminar planned: ‘Leveraging Intellectual Property for Success’

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MArk Radtke

Mark Radtke

OMAHA, Neb. (April 5, 2018)—A free seminar covering the importance of intellectual property for startups, small businesses, independent inventors, students and entrepreneurs will be held at the University of Nebraska at Omaha on Monday, April 16, 2018.

Hosted by UNO’s Nebraska Business Development Center, Mark Radtke of the United States Patent and Trademark Office, will deliver “Leveraging Intellectual Property for Success.” Radtke is the Assistant Director of the Rocky Mountain Regional USPTO. He will also be available for one-on-one meeting and small group discussions immediately following the presentation.

The talk is planned for 2-4 p.m. in the Mammel Hall auditorium at UNO’s College of Business Administration at 6708 Pine Street. Free parking will be availing in Lot 5 from 1-6 p.m.

The seminar is free and open to the public.

Any questions should be directed to Wei Jing of the Nebraska Business Development Center at wjing@unomaha.edu.

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Skin holds off nearly all infections, but no match for biofilms

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Bacterial infections are a glitch.

The marvel that is the human immune system keeps us safe from billions of microscopic organisms every day. Skin may not look like much more than a soft and fragile surface, but intact and healthy, it represents an impenetrable wall, equipped with security sensors, armed guards, and decked out in a variety of traps, snares and proximity mines for good measure.

Cheer up kid, it’s worse than it looks. If we can get past the pattern-recognition receptors, those murderous macrophages, pools of acid sweat and gooey oils, those infernal helper bacteria— traitors!— and these new-fangled antimicrobial peptide bombs... we’ll still have all the internal defenses to deal with. But, we gotta’ job to do, kid... you didn’t wanna’ live forever, did you?Innate immunity is formidable: The result of an evolutionary arms race with pathogens that has spanned several hundred million years. The human immune system is really a combination of two overlapping systems: innate and adaptive immunities. While both are important, the ancient innate immune response is comprised of nonspecific defense mechanisms that form the first response to pathogens. Adaptive immunity is much more specific; it learns to specifically target pathogens we have already encountered and, therefore, are likely to encounter again.

Bacterial pathogens only stand a chance when things go wrong. And any medical procedure presents an opportunity for things to go wrong.

A breach in the skin—from a cut, for instance—creates the possibility for surrounding pathogens to enter the body. This is why, given the option, surgical procedures, like implanting a medical device, aren’t just performed anywhere. If cleanliness is next to godliness then the operating room is a holy temple. If bacteria get through that first line of defense, they can cause tissue or organ specific infections or even systemic infections with fatal outcomes.

XKCD.comImplanted medical devices are a double-edged sword, then. On one hand, they are a modern miracle of biomedical engineering; providing a synthetic solution where nature has failed. On the other hand, they represent a literal chink in the armor.

For reasons that aren’t yet completely understood, opportunistic pathogens are highly attracted to these implanted medical devices. Once discovered, the bacterial invaders quickly go to work colonizing the implant until a mature community, or biofilm, is established.

If the bacteria are allowed to establish a biofilm, it has successfully beaten the immune response. About the only option left is to relinquish the territory and hopefully contain the bacteria to that one location in the body. And because antibiotics are impotent against bacterial biofilms, the only effective solution is total removal of the implanted device along with any infected surrounding bone and muscle tissue. If that doesn’t sound bad enough, the patient is also at a significantly increased risk for recurrent infection on any new device.

But if a medical device could be imbued with its own innate immunity, then the implant would be more like human skin. The implant could prevent bacterial attachment and inhibit biofilm formation.

Researchers have long been focused on discovering ways to prevent bacterial biofilm formation on medical devices by modifying the material surface properties. But what if the best solution is simply to think of the implant surface as an extension of the natural surfaces in our body? The first line of defense for these natural surfaces isn’t special patterning or unique physical properties, but innate immunity.

Guangshun Wang, PhD, at UNMC, has designed antimicrobial peptides to coat the surface of metallic orthopedic implants, and specifically target MRSA. Not only do these proteins prevent MRSA biofilm formation, but they also recruit host immune cells to help clear any opportunistic bacteria.

The preliminary data looks promising, with impressive effectiveness against MRSA biofilms. Dr. Wang is now seeking corporate partners to sponsor additional proof-of-concept research specifically focused on coating orthopedic implants. The hope is that by adding these peptides to the implant’s surface, Dr. Wang’s technology will effectively imbue the medical device with its own first line of defense.

 

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UNMC-UNO Innovation Accelerator meets for first time

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The first UNMC-UNO Innovation Accelerator Gathering was held earlier this week, an event that was organized in part by the UNMC Department of Emergency Medicine's Research Coordinator, Thang Nguyen (at left). UNeMed's Michael Dixon (upper right) and Deepak Khazanchi, Associate Dean of UNO's College of Information Science and Technology. were also on hand.

The first UNMC-UNO Innovation Accelerator Gathering was held earlier this week, an event that was organized in part by the UNMC Department of Emergency Medicine’s Research Coordinator, Thang Nguyen (at left). UNeMed’s Michael Dixon (upper right) and Deepak Khazanchi (lower right), Associate Dean of UNO’s College of Information Science and Technology. were also on hand.

OMAHA, Neb. (Feb. 21, 2018)—The University of Nebraska Medical Center hosted today the first UNMC-UNO Innovation Accelerator Gathering, a small meet-and-greet between the College of Medicine’s Department of Emergency Medicine and the University of Nebraska at Omaha’s College of Information Science and Technology.

The informal meeting was held in the Linder Reading Room at the Michael F. Sorrell Center. The stated goal was the hope of fostering more collaborative projects between the two campuses.

“We wanted to get the channel open so there are no road blocks because there are so many great ideas,” said event organizer Thang Nguyen, MSN, FNP-C. Also a doctoral candidate at UNMC, Nguyen is the research coordinator for UNMC’s Emergency Medicine program, and an Advanced Practice Provider for Nebraska Medicine’s emergency department.

At the meeting, departmental leaders outlined for the group major areas of research interest and clinical expertise. They also suggested how those areas of interest and expertise might overlap, perhaps opening the door to future collaborations.

Michael Dixon, PhD, UNeMed’s President and CEO, also addressed the group with brief remarks. He explained how the University’s tech transfer and commercialization office in Omaha can help support the innovations that might grow from those collaborations.

“We just want to be a resource for you,” Dixon told the group. “Hopefully help commercialize your inventions and ideas into products that can go market and actually do what we all want them to do, which is help people live healthier lives.”

Future meetings are not yet planned, but a steering committee was established to help guide potential collaborators, ideas and projects.

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Nebraska lands top Pipeline awards

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Kansas City, Missouri (Jan. 25, 2018)—Nebraska entrepreneurs  were the toast of the show at a regional entrepreneurial awards ceremony last week, receiving recognition for entrepreneurial leadership, best pitch, growth and the Innovator of the Year.

During Pipeline’s annual The Innovators awards ceremony, Omaha startup founder and Nebraska native Evan Luxon was named the 2017 Innovator of the Year. Luxon, the co-founder of Centese—formerly known as Esculon—also won the Innovator Pitch Competition.

Last fall, Centese was among the first startup companies to sign on with UNMC’s incubator program, UNeTech. Centese is developing a self-cleaning chest tube that would be less likely to become blocked or clogged.

Nebraska also claimed the Entrepreneurial Leadership awards for the continued support and advocacy from the University of Nebraska, Nelnet, Prairie Ventures and Linseed Capital. The University of Nebraska’s Pipeline sponsorship includes contributions from UNeMed, UNeTech and the University’s tech transfer office in Lincoln, NUtech Ventures.

Pipeline is an entrepreneurial mentoring program in the Midwest that offers a handful of highly selective entrepreneurial fellowships each year. Fellows in the Pipeline program received hands-on training from successful entrepreneurs and mentors from around the region and across the nation. The program helps fellows refine their business plans, raise money and dramatically improve their chances for ultimate success.

The program culminates with the annual Innovators awards celebration.

Nebraska won a fourth award, the Pipeline Entrepreneur Growth award, which was presented to Lincoln resident and Bulu Box co-founder Paul Jarrett.

This also marked the first year that a UNMC student was selected to represent the University of Nebraska system in Pipeline’s Spotlight Entrepreneur program. The program allowed four student entrepreneurs to present their business plans at the pitch competition and to be recognized before an estimated 600 attendees at the awards show.

William Payne, a UNMC doctoral student of pharmaceutical sciences, presented his company, Simple Vet Solutions. It’s a software service that eliminates the extra time and energy required to meet FDA regulations for animal medications.

Simple Vet Solutions, according to the executive summary in the business plan, offers “secure and compliant management of veterinary prescriptions and feed directives for any size of livestock operation, veterinary practice, or feed distributor.”

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UNO, UNeMed expand tech transfer relationship

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OMAHA, Neb. (January 22, 2018)—The University of Nebraska at Omaha and UNeMed, the technology transfer office at the University of Nebraska Medical Center, have signed a new services agreement for UNeMed to be the exclusive agent for UNO.

“We’ve worked with UNeMed in the past, and it always went well,” said UNO Associate Vice Chancellor Scott Snyder, PhD “We wanted to make that process easier and more efficient for everyone, and this arrangement does that.”

Dating back to the mid-1990’s, UNeMed has received about 50 new inventions from UNO inventors. Most UNO inventions, however, are more recent, emanating from UNO’s cutting edge Department of Biomechanics. Perhaps one of UNO’s more noteworthy innovations led to the creation of a new startup company, Avert, which promises to help athletic teams quickly and accurately diagnose concussions.

The new arrangement with UNeMed removes many institutional hurdles, allowing faculty, students and staff at UNO to work directly with the technology licensing experts at UNeMed.

Michael Dixon

“This is perfect for us,” UNeMed president and CEO Michael Dixon said. “We have a long history of working with UNO, and many UNMC researchers have strong collaborative ties to UNO. Hopefully, this will allow us to partner more with UNO researchers and help develop their innovations into products that can have a positive impact in the market.”

Common at virtually every major university in the nation, technology transfer offices work to protect the discoveries, innovations and inventions of their researchers. Tech transfer offices like UNeMed help identify industrial partners that can bridge the funding gap between a discovery and a product on store shelves.

“To have the expertise and experience of the people at UNeMed at our disposal is a huge asset,” Snyder said. “This should be a huge boost for many of our faculty, students and staff that want to see their ideas developed into products that help people.”

Initially established in 1991 as the tech transfer office for the University of Nebraska Medical Center, UNeMed now serves all University faculty, students and staff at both Omaha campuses and the College of Dentistry in Lincoln. UNeMed’s sister office, NUtech Ventures, serves the remainder of the University’s resources in Lincoln and Kearney.

Working primarily with academic researchers and inventors, UNeMed protects University discoveries and innovations, securing 489 patents over the last quarter century. With 106 years of combined technology development and commercialization experience, UNeMed staffers help propel those innovations through development into products that help improve the lives of people everywhere.

Virtual Incision’s robots are on the verge of transforming complicated, highly invasive open surgeries into relatively simple laparoscopic procedures.

Common routes to commercialization include establishing relationships with industrial partners for sponsored research agreements, signing licensing agreements with established commercial entities or building new startup companies. For example, a UNMC surgeon and a UNL engineer collaborated on a surgical robotic device to create Virtual Incision, a biomedical startup. Virtual Incision recently announced a successful Series B financing round of $18 million.

Virtual Incision is just one of 58 new startups UNeMed has help build in its 26-year history. UNeMed has also helped UNMC secure an additional $6.32 million in sponsored research while processing more than 1,330 new inventions from University faculty, staff and students.

Those 1,330 inventions eventually resulted in 230 licensing agreements over the years, which amounts to a track record that helped place the University of Nebraska 35th out of 230 in a recent report from the Milken Institute, a non-partisan think tank. The placement puts UNeMed, NUtech Ventures and the University of Nebraska in the top 15th percentile.

The 2017 report ranked the University of Nebraska’s tech transfer efforts ahead of such institutions as the Mayo Foundation (36), the University of Wisconsin (39), Ohio State University (55), and the University of Iowa Research Foundation (59), to name a few.

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How we can help: Licensing and startups

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by Catherine Murari-Kanti, UNeMed | January 10, 2018

Part seven of a series

As part of UNeMed’s research commercialization activities, we routinely seek industrial partners to license University of Nebraska innovations. For this purpose, the University and industrial partners set up license agreements that describe the rights and responsibilities related to the use and exploitation of the intellectual property.

Licensing associates at UNeMed diligently market and license Nebraska’s technologies to appropriate industrial partners. Licensing significantly reduces researchers’ devotion of time and money. The licensee generally has significant financial, physical and labor resources to commercialize University intellectual property, allowing the masses to benefit from technologies developed at the University of Nebraska.

License agreements usually cover four key areas:

  • They stipulate that the licensee will diligently seek to bring the University’s intellectual property into commercial use for the public good.
  • Plan specified milestones that hold the industrial partner to keep up with the development and commercialization of the technology.
  • Financial obligations like up-front license fees, milestones, royalties and minimum payments and maintenance fees. Agreements sometimes make licensees responsible for paying all incurred and future patent expenses.
  • Provisions for a reasonable monetary return to the University.

Inventors participate in any financial returns from a license in terms of earned royalties, milestone fees and minimum royalties. In addition, inventors enjoy the satisfaction of knowing their inventions benefit the general public.

License agreements vary in length and complexity depending on a of myriad factors such as the type of licensed technology, scope of patentability, the particular industry involved and the relationship between the licensee and licensing parties.

Under certain conditions, UNeMed will license technologies and assign all its rights back to the inventor to develop the technology. This usually leads to the development of a startup.

A few factors when considering a startup company:

  • Is your technology is in its nascent stages and requires additional development before a licensee can take it over?
  • How much is it going to costs to develop the technology and if investors would be willing to put that money in?
  • Is it possible for the inventor to develop multiple products from the same technology, maybe even target different markets – providing a larger competitive advantage?

The choice to establish a new company is a joint decision made by UNeMed and the inventor.

Of course, we do not expect you to do this alone. UNeMed will advise and provide the right coaches and resources to help set up the startup.

The primary inventor on the New Invention Notification form is typically the founder of the company. Most faculty will wear two hats–one as faculty and one as the CEO of the startup. Very rarely does a University of Nebraska faculty leave to run a startup. Faculty involvement of any kind in a startup is reviewed for conflict of interest.

It is important to remember that a startup is like a baby. Startups require a considerable amount of tender, loving care to grow and develop. The primary inventor will need to champion the effort in setting up a management team and recruiting other members required for the company to survive and eventually thrive.

UNeMed has a list of successful startups and is consistently playing an active role in educating, advocating and mentoring new entrepreneurs.

This was the final installment in a series of blog posts covering the many services UNeMed provides for faculty, students and staff at UNMC and UNO. Here’s the full list of topics:

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