Husker halftime show to feature Dixon

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LO_michael_dixon_2014_croppedLINCOLN, Neb. (Oct. 16, 2014)—UNeMed president and CEO Michael Dixon will be interviewed by Greg Sharpe, the “Voice of the Huskers,” which will broadcast during halftime of Nebraska’s football match-up with Northwestern on Saturday, Oct. 18.

The interview is a part of a regular series of halftime interviews that will include University of Nebraska interim president Jim Linder. In the series, Linder and Sharpe meet with various University officials to discuss the University’s economic impact on Nebraska. This week, Sharpe and Dixon will discuss UNMC research and the University’s technology transfer efforts.

Kick-off for the Cornhuskers’ road game at Northwestern University is listed at 6:30 p.m. The Husker Sports Network will carry the game, and a list of broadcast affiliates can be found here. In Omaha, KFAB (1110 AM) will carry the game and halftime interview. It can also be heard through the iHeartRadio Network’s smartphone application and SiriusXM.

Dixon and Sharpe are also expected to discuss some of the cutting edge research at the University of Nebraska Medical Center, and the value those innovations bring not just to the local economy but to the general well-being of everyone on the planet.

Dixon is also expected to talk about Omaha’s growing startup and entrepreneur community, and how the University should fit into that part of the ecosystem.

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UNeMed to give away free iPad…again

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Free iPadOMAHA, Neb. (Oct. 16, 2014)—UNeMed Corporation, the technology transfer office at the University of Nebraska Medical Center, will once again give away a free iPad during Innovation Week.

Open to all UNMC students, faculty and staff, the drawing will be held during the Innovation Awards Ceremony and Reception, which is scheduled for Thursday, Oct. 23 at 4 p.m. in the Durham Research Center auditorium. The entrant must be present to win.

Innovation Week is a series of events hosted and sponsored by UNeMed as an annual showcase that honors and celebrates the innovative and ground-breaking research performed at UNMC. The week culminates with the Innovation Awards, which specifically recognizes those who submitted a new invention, licensed a technology or received a U.S. patent during the previous fiscal year.

2014 UNeMed T-shirtsUNeMed will also present two special awards to the Most Promising New Invention of 2014 and the 2014 Emerging Inventor.

To enter the iPad drawing, UNMC personnel can register by attending any Innovation Week event. Every Innovation Week event represents an opportunity for an additional entry in the drawing pool.

Innovation Week kicks off Monday at 9-11 a.m. with an open house to meet and mingle with UNeMed staff who will be handing out an assortment of goodies, including UNeMed T-shirts. Jo-On-The-Go will also provide free coffee and smoothies.

jonthegol_LOMonday also marks the opening day of the first-ever UNeMed scavenger hunt.

The final event on Monday is the “Bioscience Week Kick-off Reception,” at Baird Holm (1700 Farnam St., Omaha) at 4-6 p.m. The Kick-Off is part of a state-wide focus on bioscience innovation and collaboration and is co-sponsored by BioNebraska, UNeMed and NUtech Ventures, the tech transfer office for UNL.

Innovation Week continues Tuesday with two events, an educational seminar aimed at stoking better university-industrial collaborations, and the second annual UNMC Technology Demonstration Day.

Toru Seo, PhDThe seminar will be presented by Taisho Pharmaceutical Co.’s Deputy General Manager for Licensing and Business Development, Toru Seo, who will discuss how and why government, academic and industrial researchers can and should build stronger partnerships. It will be held in room 1004 in DRCI, and a complimentary snack will be provided.

Demo Day will be held at 3-5 p.m. in the DRC auditorium and will feature six leading technologies that emanated from the research laboratories at UNMC and UNO. The technologies will be presented by researchers, company CEOs or startup founders in easy-to-understand 10-minute sessions intended for scientists and non-scientists alike. Demonstrations will be followed by a short reception with complimentary food and wine.

COPD Detection Platform HardwareOn Wednesday, BioNebraska will present “Experiencing Biotechnology,” a panel discussion at the Beadle Center in Lincoln. Hosted by UNL’s Department of Biochemistry, the discussion is expected to address the challenges facing the future of drug development, animal health, agriculture and devices.

Wednesday also marks the close of the Scavenger Hunt with the entry deadline set for 4:59 p.m.

Innovation Week in Omaha concludes Thursday with the Awards Ceremony.

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Pipeline alum signs research deal with UNeMed, will speak at Innovation Week

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OMAHA, Neb. (Oct. 15, 2014)—A new sponsored research agreement between a University of Nebraska Medical Center scientist and an industrial partner will look to produce the next generation of safer, more effective surgical meshes.

Matthew MacEwan

Matthew MacEwan

Matthew MacEwan, an alum of Pipeline’s 2012 fellowship class and the President at Acera Surgical Inc., signed the research partnership, which will explore clinical applications for a new invention developed in UNMC’s College of Pharmacy. MacEwan will also discuss the new technology as one of the featured presenters during the second annual UNMC Technology Demonstration Day on Tuesday, Oct. 21.

Demo Day is a forum highlighting some of the most advanced and promising new technologies emerging from UNMC research laboratories. It is among several events during Innovation Week, which is hosted every year by UNeMed, the technology transfer office for UNMC.

The new partnership was partly a result of UNeMed’s relationship with Pipeline, a regional entrepreneurial program that recently expanded its reach to include all of St. Louis. Until recently, Pipeline’s reach into St. Louis was limited to those associated with Washington University, such as MacEwan who entered the program while pursuing an M.D./PhD

Acera Surgical Inc. is a surgical device startup company based in St. Louis, specializing in the next generation of surgical materials. Its cornerstone product, CeraFix™ Dural Substitute, is an implantable biosynthetic material, or scaffold, for use in brain surgery. CeraFix™ is under review by the FDA and is not yet available for clinical use or sale.

Acera will perform additional testing on existing materials using a new method developed by Jingwei Xie, PhD, an assistant professor in UNMC’s Department of Pharmaceutical Sciences.

Dr. Xie recently developed a new process for producing three-dimensional nanofabricated materials and matrices.

“Our goal is to give surgeons a new option when it comes to implantable materials,” MacEwan said. “We are very excited by the work that Dr. Xie is doing, and we believe the process he’s developing will lead to a new generation of medical devices that may improve clinical care for a large number of patients.”

In healthcare, synthetic nanofabricated materials are commonly used as bandages, to deliver drugs, or even engineer and repair tissue. Nanofiber matrices are also used in engineering as filters and membranes; in solar cells and fuel cells; and as chemical and biological protection sensors in defense and security applications.

When existing nanofiber materials are treated with the new process, the materials show a significant increase in porosity, which makes them more effective as tissue and cellular scaffolds. The materials may also be more absorptive and provide a unique substrate for cell cultures, according to early studies.

Acera will also explore creating entirely new products based on Dr. Xie’s work.

The first round of testing is expected to occur over the next six months, and, if successful, could lead to a deeper partnership between Acera and UNMC. Acera may explore additional opportunities in the Omaha area if early experiments lead to a new product, MacEwan said.

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Tyler Martin joins UNeMed board of directors

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Tyler Martin, M.D.OMAHA, Neb. (Aug. 5, 2014)—UNeMed Corporation announced at its annual shareholder meeting that Tyler Martin, M.D., has been added to the board of directors.

Martin, a product of Hebron, Neb., joins UNeMed after a long stretch of success in Silicon Valley where he helped build new startups and managed established biotech companies. His experience in ushering several new therapeutics through an arcane and complicated regulatory process could be particularly valuable to UNeMed, which is the technology transfer office for the University of Nebraska Medical Center in Omaha.

“We’re thrilled to have someone with his expertise back in Nebraska, helping build the biotech industry in the state,” UNeMed president and CEO Michael Dixon said. “He’s been building biotech companies and bringing new drugs to market for two decades, so he brings in a wealth of industrial and clinical knowledge.”

A pediatrics and infectious disease expert, Martin received his M.D. from UNMC in 1986. More recently, he managed Dynavax Technologies Corporation as the biopharmaceutical company’s president and Chief Medical Officer.

Martin returned to Nebraska in 2013, founding a biotechnology consulting firm, Great Plains Biotechnology, in the Lincoln area. He is also the CEO of Adjuvance Technologies Inc., a private pharmaceutical company specializing in vaccine design and production.

“My wife and I are from Nebraska, and we always thought about coming home,” Martin said. “There’s an underappreciated amount of biological talent here, and so we jumped at opportunity to help create a life science nexus in Nebraska.”

Other members of the UNeMed board are Dixon, Chairman Don Leuenberger, Director Terry Opgennorth, PhD, and Richard Spellman.

Leuenberger is UNMC’s Vice Chancellor for Business and Finance; Dr. Opgenorth is the vice president at CSU Ventures, Colorado State University’s technology transfer office; and Spellman is associate general counsel for healthcare at UNMC

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Innovation Week at UNMC begins Oct. 20

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iweekbadge2014OMAHA, Neb. (Oct. 13, 2014)—The eighth annual Innovation Week kicks off Monday, Oct. 20, and will celebrate and recognize the world-class research and discovery at the University of Nebraska Medical Center.

Hosted by UNMC’s technology transfer office, UNeMed Corporation, Innovation Week begins with an open house 9 a.m. Monday, and culminates with the UNMC Research Innovation Awards Ceremony and Reception Thursday evening, which will include a drawing for a free iPad.

Reserve your seat today. Click here.Innovation Week will also feature a seminar about industry-academia collaboration from Taisho Pharmaceutical’s deputy general manager, Toru Seo, PhD Innovation week will also see the return of UNMC Technology Demo, and UNeMed will host for the first time a scavenger hunt.

All events are free and open to the public, but the iPad drawing is for UNMC faculty, students and staff only. They may register for the drawing by attending any Innovation Week event.

Demonstration Day will feature six technologies that were invented and developed at UNMC. The innovations are either the basis for a new startup company or are partnered with industrial collaborators for further development. Representatives will present 10-minute demonstrations intended for a general public. Short Q&A sessions will follow each presentation.

Demonstration Day is planned for Tuesday, Oct. 21, beginning at 3 p.m. in the auditorium of UNMC’s Durham Research Center, and will conclude with a short reception with food and drinks. Seats may be reserved at https://unmcdemoday14.eventbrite.com.

Reserve your spot at Demo Day here.Also on Tuesday, Oct. 21, Toru Seo will present a seminar about building better collaborations between academia and industrial partners. That talk will be held in room 1004 of DRC I, beginning at 10 a.m. A light snack will be provided.

awardsleft_LOInnovation Week concludes on Thursday, Oct. 23, with the UNMC Research Innovation Awards Ceremony and Reception. The ceremony will recognize all the UNMC scientists over the previous year who were issued a new patent, licensed a technology, or developed a new invention. UNeMed will also present special awards for the “Most Promising New Invention of 2014” and the “2014 Emerging Inventor.”

Seats for the Innovation Awards may be reserved at https://iw2014.eventbrite.com.

Monday’s open house is a chance to meet UNeMed staffers, learn about the innovation process, and pick up free T-shirts, pens, notepads, and beverages provided by Jo-On-The-Go.

More details about the scavenger hunt will be available soon, and announced through UNeMed’s Facebook page and Twitter feed.

All events will be held at the Durham Research Center on the west end of the UNMC campus, about one block north of Emilie and South 45th Streets.

More information about Innovation Week will available on UNeMed’s website at https://www.unemed.com/innovation-week.

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Pharmaceutical executive to speak at Innovation Week event

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Innovation Week 2014OMAHA, Neb. (Oct. 14, 2014)—Bridging the gap and building better relationships between university researchers, potential industrial partners and governmental agencies will be the topic of UNeMed’s Innovation Week seminar Tuesday, Oct. 21.

Toru Seo, PhD, will deliver a presentation entitled “Omnia Mutantur Nos Mutamur In Illis: What we can learn from Charles Darwin.” Translation: “All things change, and we change with them.”

“This famous Latin phrase,” Dr. Seo said via email, “nicely illustrates how we should be thinking.”

Toru Seo, PhDDr. Seo is the deputy general manager for licensing and business development at Taisho Pharmaceutical Co., LTD, which is based in Tokyo. The seminar will be held in Room 1004 in the Durham Research Center I at 10-11 a.m. on Tuesday, Oct. 21. A complimentary light snack will be provided.

“While an alliance of government, academia and industry has been in development for decades, the outcomes of this ‘consortium’ are not necessarily maximized to their full potential,” Dr. Seo said. “The aim of the lecture is not to evaluate the alliance in entirety, but to focus on how we can better leverage each party and to share some perspectives to better achieve an efficient and productive alliance based on my experience.”

Sponsored by UNeMed Corporation, the seminar is a part of Innovation Week, a series of events celebrating the innovation and research at the University of Nebraska Medical Center.

Innovation Week begins Monday, Oct. 20 at 9 a.m. in the DRC-I atrium with an open house where visitors can register for a chance at a free iPad, and pick up a free UNeMed T-shirt and other goodies. UNeMed will also offer free beverages from Jo-On-The-Go.

Also on Tuesday, beginning at 3 p.m., UNeMed will host the UNMC Technology Demonstration Day in the DRC-I auditorium. Demo Day is a free and open event featuring 10-minute presentations about innovations developed by UNMC researchers. To attend, register at https://unmcdemoday14.eventbrite.com.

Innovation Week culminates on Thursday, Oct. 23 with the UNMC Research Innovation Awards Ceremony and Reception beginning at 4 p.m. The awards ceremony will recognize the new inventions, patents and licensed technologies at UNMC over the previous year, and UNeMed will also present two special awards honoring an “Emerging Inventor” and the “Most Promising New Invention.”

The free iPad winner will also be announced during the ceremony, but the entrant must be present to win. To attend, register at https://iw2014.eventbrite.com.

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UNMC Technology Demonstration Day planned for Oct. 21

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demodaybanner14EBclearOMAHA, Neb. (Oct. 3, 2014)—The public will get the rare chance for a close and personal look at innovative technologies emerging from the research labs at the University of Nebraska Medical Center.

Sponsored by UNeMed Corporation, the second annual UNMC Technology Demonstration Day will be held Monday, Oct. 7, at 2:30 p.m. in the Durham Research Center I auditorium. UNeMed is the technology transfer office that helps UNMC’s groundbreaking research go beyond the laboratory.

Demonstration Day is a free and open event that will feature about six technologies (see below) developed at UNMC. Most of the featured innovations are either the cornerstone of a new local startup, or have been licensed by an existing company for further development. Inventors, startup CEOs or their representatives will deliver a short, 10-minute presentation, followed by a brief question and answer forum. UNeMed will then host a reception in the atrium with complimentary food and refreshments.

Space is limited, but a seat for UNMC Technology Demonstration Day can be reserved at https://unmcdemoday14.eventbrite.com.

UNMC employees and students who register online will also be automatically entered for a chance to win a free iPad, which will be announced at the Innovations Awards ceremony.

Innovation Week kicks off with an open house Monday, Oct. 7, at 9 a.m. in the DRC I atrium, where visitors can register another entry for the free iPad drawing, and pick up a free UNeMed T-shirt and other goodies. UNeMed will also offer free beverages at the open house.

UNeMed will host a seminar about building better collaborations between academia and industrial partners on Tuesday, Oct. 21 beginning at 10 a.m. UNMC personnel who attend the seminar will also gain an additional entry for the iPad drawing.

An on-campus scavenger hunt will wrap up Wednesday, awarding prizes to the winners who accumulates the most points. Go to the UNeMed’s Innovation Week webpage for additional details on the scavenger hunt.

Innovation Week culminates on Thursday, Oct. 23 with the UNMC Research Innovation Awards Ceremony and Reception beginning at 4 p.m. At the conclusion of the awards, UNeMed will draw for the free iPad 2. The winner must be present to claim the prize or a new name will be drawn.

The event is free, but space is limited, so reserve a seat for the Innovation Awards at https://iw2014.eventbrite.com.

SCHEDULED TECHNOLOGIES:

Shared data needs middleman — Labpoint president and founder John Glock will discuss his Omaha startup’s climb from an idea to a working web solution that help labs, clinics and hospitals increase efficiency by improving their ability to share critical information despite using different hardware and software platforms. Labpoint was created in 2007, born from an idea Glock had while working as an information technology manager at UNMC’s Nebraska Public Health Library.

Laparoscopic simulator for higher skills, lower costs — Developing facilities for the purpose of training and maintain laparoscopic skills often requires a dedicated space and several thousands of dollars. A new, elegant system under development at UNMC can make virtually any open space a suitable training spot for laparoscopic tools at a small fraction of the cost. UNeMed’s Joe Runge will discuss this new training tool, and the clinical needs for cost-cutting innovations.

Detecting problems before the symptoms appear — The third-leading cause of death in the United States COPD, or chronic obstructive pulmonary disease, can lead to sudden and life-threatening exacerbations—a flare-up of symptoms that often result in hospitalization and an acceleration in the loss of lung function. Patients suffering from COPD must remain vigilant for the earliest signs of an exacerbation, but remarkable research from the biomechanics facility at the University of Nebraska-Omaha, have devised a platform that detect the earliest sign of impending trouble, long before a patient ever notices any of the traditional warning signs. Researcher Jenna Yentes, PhD, will discuss a the natural biorhythms in the human system and how they can tell us what’s wrong before we even know there’s a problem.

A better blood test for heart disease — Among the modern medical mysteries has been how a person with all outward appearances of health and youth die from a sudden heart attack. Finding those people at risk for the most dangerous forms of heart and artery disease could be as simple a new blood test currently under development at UNMC. Researcher and practicing heart specialist Dan Anderson, M.D., PhD, will discuss all we know—and what we don’t—about heart disease, and how we might be able to better manage artery disease in the near future.

Reinventing the surgical mesh — Acera Surgical is a medical device startup, in St. Louis, Mo., specializing in the next generation of surgical materials. Its cornerstone product, CeraFix™ Dural Substitute, is an implantable biosynthetic material, or scaffold, for use in brain surgery. Acera Surgical recently licensed a new UNMC invention for producing three-dimensional nanofabricated materials and matrices. Acera President Matthew MacEwan will discuss the shortcomings of modern medical meshes, and how UNMC’s and Acera’s innovations are the next generation of surgical materials.

Improving the hemodialysis catheter — An interventional nephrologist at UNMC, Marius Florescu, M.D., designed a new catheter with the potential to eliminate expensive and risky procedures for patients undergoing hemodialysis—the process that filters a patient’s blood. One common complication is that the catheter through which the machine removes and replaces the blood will become blocked, requiring surgery to replace the catheter and radiological imaging to verify the repair. Chrysalis Medical is a new venture formed in San Jose, Calif., by veteran medical device professionals and will build the prototype for testing at UNMC. Chrysalis CEO Ron Allen, is expected to lead the discussion.

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Innovation Week 2014 planned, Awards is October 23

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iweekbadge2014OMAHA, Neb. (Oct. 2, 2014)—UNeMed Corporation announced today plans for Innovation Week 2014, an annual event that celebrates innovation and discovery at the University of Nebraska Medical Center.

Registration is freeUNeMed, the technology transfer office for UNMC, is hosting the weeklong series of events, which kicks of with an open house on Monday, Oct. 20. Innovation Week culminates with the Innovation Awards on Thursday, Oct. 23 at 4 p.m. in the Durham Research Center I auditorium. Awards will be presented to UNMC researchers, faculty, staff and students who developed a new invention, secured a patent, or signed a licensing agreement for an invention.

This year UNeMed will also present two special awards honoring the “2014 Emerging Inventor” and the “Most Promising New Invention.” There will also be a drawing where one person will win a free iPad.

The Innovation Awards are open to anyone who wishes to attend, but they must first register at https://iw2014.eventbrite.com.

Iawardsbanner14EBclear

Other planned events for Innovation Week include a scavenger hunt, a seminars about academic and industrial collaboration, and the “UNMC Technology Demo Day,” where researchers and startup companies based on UNMC inventions will deliver short presentations about their innovations. Demo Day is a free event but space is limited and guests are asked to reserve a seat at https://unmcdemoday14.eventbrite.com.

Innovation Week’s kick-off event on Oct. 20 will feature free T-shirts, beverages and other items.

The complete schedule of events is posted to the UNMC calendar, and more details are available on the UNeMed website at https://www.unemed.com/innovation-week.

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Scientists explore the ‘Dark Side’: Careers away from the bench

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by Agnes Lenagh, PhD, UNeMed

OMAHA, Neb. (Sept. 12, 2014)—While not all scientists accept the existence of careers outside academia or industry, universities are finding value in showcasing alternate career paths available to scientists in biomedical fields. UNMC postdoctoral scholars and graduate students had the unique opportunity Thursday to explore a career options within the legal community.

Robert Netter, PhD, J.D.

Robert Netter, PhD, J.D., a patent attorney in Philadelphia, chats with a audience member following a short presentation about alternate career paths for grad students and postdocs in scientific fields.

Robert Netter, PhD, J.D., a partner at Dann, Dorfman, Herrell, and Skillman, an intellectual property law firm in Philadelphia, took time off from his busy schedule as a patent attorney to discuss opportunities for scientists within the legal community.

Dr. Netter was once a Cell and Molecular Biology graduate student researching Ebola virus proteins. His frustrations with academia began early when his research project hit a roadblock and went off the cliff taking nine months of work with it. Adding insult to injury, his PI had just received tenure, was disengaged with his lab, and left Netter in academic limbo.

Frustrated with academia, Netter began exploring his options while still in grad school. He befriended the student across the hall, whose goal was to become a patent attorney just like her father. Netter jumped on the bandwagon and read up on the field. Following graduation and while finding a position with a law firm, Netter spent just two short months as a post-doc before he definitely “crossed over to the dark side.”

Netter recalled the challenges of his decision. At one point he was working 7-5 at a law firm; attending law school at Temple University by night; getting home to study until midnight, only to get up in the morning and do it all over again Monday through Thursday. He enjoyed Fridays because he “only had to work in the day, so Fridays were great.”

Two of his kids were also born while he was in law school: “I tried to do everything all at once, and I don’t know how I lived.” Dr. Netter is proof that if you can succeed if you set your mind to it.

At the time there was a “stigma associated with leaving academia.” Today, there are more options and support available for PhD graduates. The legal field includes positions in academic tech transfer offices, such as UNeMed; small and large law firms; government, including the United States Patent and Trademark Office; and investment banking.

“I do not know of any PhD/J.D.s who can’t find a job.”
Robert Netter, PhD, J.D.

Freshly graduated scientists with no legal training can find positions as technical advisers. This position involves what Netter later referred to as “grunt work” including writing drafts for patent applications and performing prior art searchers to help write counterarguments. Scientists benefit by becoming familiar with legalese, the language of the legal world.

Netter advised that anyone interested in the legal path should definitely become familiar with the field by working and pursuing the USPTO patent bar. Passing qualifies them as a Patent Agent capable of submitting and prosecuting patent applications. They are also taken more seriously because they demonstrate that they have invested time and money to pursue the career path.

Scientists that go to law school and pass another bar exam then become Patent Attorneys and have a shot at becoming partners at a firm someday.

Dr. Netter still uses his PhD skills every day. “I still like to consider myself a scientist first, and an attorney second,” he said. The job is challenging, yet satisfying as Netter works with government bureaucrats who can be difficult. He also works with universities and appreciates helping the “underdog.” It’s a stable career that is also financially rewarding, particularly after making partner, he said.

However, the grass doesn’t start out green on the other side. Choosing to follow a legal career guarantees a long road and it’s hard to start over, especially after completing a PhD program. All that PhD training in the lab is good practice for enduring the long, stressful hours that can come with the legal field. It’s also a service industry, and clients always come first. Clients must always be happy because no clients, means no job.

Another drawback to working in the legal field?

“Wearing these stupid suits,” he said. “I’d rather be wearing jeans and a T-shirt.”

But suits come with the territory, and there’s always the weekend.

———

Agnes Lenagh, PhD, is a postdoctoral fellow at UNeMed, working as a licensing associate. She also uses her PhD training every day in helping scientists move their work forward, toward improving people’s lives.

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Why we care about the startup and entrepreneur communities

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By Charles Litton, UNeMed | Sept. 10, 2014

There are some things we do that have a hidden and seemingly unknowable value.

We carefully tend to a garden never knowing when, if ever, a sprout will appear, or even if any seeds were planted in the first place.

We don’t often print large stories about these efforts, or issue press releases, or rattle off large, up-and-to-the-right line charts in our annual reports.

Yet we do them all the same.

This, of course, might seem rather silly, and it’s tempting to ask our president, Michael Dixon, why we bother.

Michael Dixon, PhD

Michael Dixon, PhD

Why spend so much time working with and thinking about the startup and entrepreneurial communities in the city, state or even the entire Midwest region? Specifically, why involve ourselves with groups like Pipeline, NMotion, Straight Shot and others?

The response will invariably include words like “nurture” and “ecosystem” and a lot of plural pronouns.

It’s about “we” and “us” and “our.” And not the “we” as in “We, UNeMed” or “We, the University.”

It’s bigger than that.

This larger concern for the entire ecosystem goes back, no doubt, to our previous president, who, as fortune would have it, now sits in the big chair in Lincoln as the interim president of the University of Nebraska.

Jim Linder

Jim Linder, M.D.

But before Dr. Jim Linder reached such heights in the University system, he oversaw our little corner of the universe. First he was our president, then he was the president of the University Technology Development Corporation, which oversees all tech transfer efforts across all campuses.

He saw a small garden worth tending.

So UNeMed jumped with both feet into Pipeline’s mission of supporting, advising and mentoring aspiring entrepreneurs in the Midwest—particularly those who are looking to build the kind of high-tech, high-growth startups that drive economic rebounds in cities like Omaha, Kansas City and St. Louis.

So it’s intensely gratifying to see that investment of time and energy has paid off in some small measure.

Dixon, our current president—and a Linder protégé—serves as a regional network adviser for Pipeline. When Pipeline morphed into a regional program three years ago, Dixon crossed paths with an entrepreneurial M.D./PhD candidate from St. Louis who was among the 100s of applicants for Pipeline’s annual fellowship program. Matthew MacEwan graduated in Pipeline’s 2012 class, and he maintained the network of advisers and mentors he built while in the exclusive program.

Matthew MacEwan

Matthew MacEwan

MacEwan is now the President and Chief Scientific Officer at Acera Surgical, Inc. — a St. Louis-based startup working on the next generation of nanofabricated surgical meshes.

It so happens that we have a researcher who invented a new method for creating better medical meshes.

What happened next should be obvious.

Dixon called it the “perfect partnership.”

It happened because we had, and still have, leaders who see that the value of the University is tied to the value of the ecosystem.

And that caring for a patch of fertile soil in the backyard is worth a little extra time and energy.

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New seminars will discuss careers away from the bench

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OMAHA, Neb. (Sept. 10, 2014)—A new seminar series aimed at postdoctoral scholars and graduate students will address alternate career paths available to scientists in biomedical fields.

Hosted by the University of Nebraska Medical Center Postdoctoral Association in collaboration with UNeMed Corporation, UNMC’s technology transfer office, the new series will examine careers away from the bench in four planned talks beginning in September.

The series opens at noon on Thursday, Sept. 11, in room 1004 at the Durham Research Center, when patent attorney and biologist Robert Netter, PhD, J.D., discusses opportunities for scientists within the legal community.

Netter works at Dann, Dorfman, Herrell, and Skillman, an intellectual property law firm in Philadelphia. He earned his doctorate in cell and molecular biology from the University of Pennsylvania in 2002, and then received his law degree from Temple University in 2007. Netter specializes in patent law, primarily serving universities and small to mid-sized biomedical companies.

More sessions are planned, and further details will be announced when those sessions are finalized.

All seminars are free and open to the public, and refreshments will be provided.

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Containing Ebola means we must care for the caregivers

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by Joe Runge, UNeMed | Sept. 5, 2014

Dr. Rick Sacra, an assistant professor at the University of Massachusetts Medical School and a missionary with SIM, contracted Ebola while volunteering at the ELWA Hospital in Monrovia, Liberia. His wife, Debbie, explained that he was not “someone who can stand back when there is a need that he can take care of.”

Ebola virus infects a cell

This digitally-colorized scanning electron micrograph depicts numerous filamentous Ebola virus particles (blue) budding from a chronically-infected VERO E6 cell (yellow-green).
(Photo: National Institute of Allergy and Infectious Diseases)

That need was not treating patients with Ebola, but caring for pregnant women in the shattered and overwhelmed Liberian healthcare system. By doing that, Dr. Sacra was indirectly contributing to the containment of the deadliest Ebola outbreak in history, and to the health and safety of everyone.

It is hard to get volunteers to treat such a deadly disease, especially in such an under-resourced part of the world. The risk is deadlier when basic protective equipment like gloves and gowns are in short supply. It is, however, the doctors, nurses and volunteers who contain the epidemic. To stop the disease, they risk their lives.

What are we to do when the people protecting us from Ebola are infected?

Dr. Sacra has paid a terrible price for his part in containing the disease. Mercifully, his chances of surviving the infection are dramatically better. He will receive proper care in one of the four places in the United States qualified to treat him safely—the University of Nebraska Medical Center.

It is cruel that most caregivers and patients afflicted with Ebola are not afforded the best possible care. It is also cruel that so many caregivers do not get the benefit of UNMC’s advanced Biocontainment Facility. It is, however, a privilege to take care of Dr. Sacra, and help him fight off this deadly infection.

His transport to UNMC does carry risk, but only to the people in direct contact with him: The brave air crew and emergency personnel that brought him to UNMC, and the dedicated staff of the Biocontainment Facility that will care for him. Even with state of the art protection, the personal risk to all of them is still very real.

Ebola is scary, but the risk to Omaha is not from Dr. Sacra. It is from an uncontained epidemic a continent away.

I am proud to be part of an institution that, in a very public way, is helping to contain the crisis. Bringing Dr. Sacra to Omaha makes everyone safer by reassuring caregivers that we will not turn our backs when they can be safely cared for.

Welcome to Omaha, Dr. Sacra. We will have you back in Massachusetts in no time.

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UNeMed shareholder meeting outlines tech transfer success in 2014

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by Charlie Litton, UNeMed

OMAHA, Neb. (August 7, 2014)—Researchers at the University of Nebraska Medical Center are among the most inventive in the country, according to information provided to an exclusive audience of administrators, faculty and staff during UNeMed Corporation’s shareholder meeting Tuesday evening at TD Ameritrade Park’s Skybox Lounge.

Chancellor Jeffrey P. Gold, M.D.

University of Nebraska Medical Center Chancellor Dr. Jeffrey P. Gold addresses guests of the UNeMed Corp. Shareholder Meeting on Aug. 5, 2014, at TD Ameritrade Park in Omaha. (Photo: Charlie Litton/UNeMed)

The meeting featured brief remarks from UNMC Chancellor Jeffrey P. Gold, M.D., who outlined his support for commercialization efforts. He was followed by Michael Dixon, PhD, the president and CEO at UNeMed—the technology transfer and commercialization arm of UNMC.

Dr. Dixon called UNMC researchers an “inventive group,” citing the most recent data from the Association of University Technology Managers, which shows UNMC’s 7.48 inventions for every $10 million spent was fifth in the nation.

“We are definitely on the national radar screen,” said Dr. Gold, referring to a national poll that predictably showed people most often associated the University of Nebraska with football. The second thing they connected to Nebraska was healthcare, according to Dr. Gold.

Dr. Dixon also noted that 75 UNMC technologies are currently under license, with 39 helping improve lives as products on the market.

Improving the “human condition” is a key component of Dr. Gold’s vision for UNMC research. He told an estimated crowd of 80 that research doesn’t end after publishing a paper in an academic journal or when a grant expires.

“The research is done when a human life is changed,” Gold said.

He added: “It’s the people in this room that carry out the final step, that take it from the laboratory into the realm of reality, so it changes the lives of patients today and tomorrow and for generations and generations to come.”

The UNMC Chancellor is the lone shareholder, serving as proxy for Nebraska’s University Technology Development Corporation, which owns UNeMed.

Dr. Dixon reported $1.17 million in total revenue during the previous fiscal year. He said it was comparable to Northwestern University before a successful licensing deal netted the Chicago-based Big Ten Conference member more than $2.3 billion with the development of Lyrica, an anti-seizure medication.

DMitry Oleynikov, M.D., (left) and Michael Dixon, PhD

UNMC researcher and surgeon Dmitry Oleynikov, M.D., (left) and UNeMed president and CEO Michael Dixon, PhD, during the UNeMed shareholder meeting. (Photo: Charlie Litton/UNeMed)

“That’s why we’re going to keep taking at-bats,” Dixon said. “Because it takes just one swing for a home run.”

Dr. Dixon presented several other “core metrics” highlighting UNeMed activities throughout fiscal 2014, including:

  • 78 new inventions disclosed
  • 315 material transfer agreements
  • 93 confidential disclosure agreements
  • 16 patents issued
  • 14 licensing agreements

UNeMed has also focused on expanding its international footprint. In the last two years, UNeMed signed licensing agreements with companies in six different countries.

D.J. Thayer and Bo Han, M.D., PhD

D.J. Thayer (left), the Director of International and Domestic Affairs for UNeMed and UNMC, chats with Bo Han, M.D., PhD, who will serve in China as a business development specialist for UNeMed Health Consulting-Shanghai (UHCS). (Photo: Charlie Litton/UNeMed)

To lead the growing international efforts, Dr. Dixon announced the addition of D.J. Thayer, who joined UNMC and UNeMed in early July as the director of international and domestic affairs. Thayer, President of infoUSA Inc. for 10 years, will lead UNMC’s international activities, particularly as it establishes operations in China. And new agreements in China are currently under negotiation, Dr. Dixon said.

He also highlighted recent fund-raising efforts for local startup companies that were built on UNMC innovations. In the last three years, UNMC entrepreneurs have raised more than $10 million in a burgeoning Omaha startup environment that CNN Money rated No. 3 in the country.

Dr. Gold concluded his remarks with the idea that research funding was not a gift, but a necessary investment for greater prosperity and health.

“It’s an investment that will convert this intellectual property—and all of your hard work in your research labs—into the future cures and the ways we prevent disease in our country and in our community,” he said.

 

 

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The next big thing: Biomechanics and your smartphone

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by Joe Runge, UNeMed | July 31, 2014

In the future, your smartphone will be able to detect your elevated risk of Parkinson’s disease, years before any conventional test reveals similar risks.

Athletes will get clear answers before returning to play after a concussion. Patients suffering from respiratory disorders will get advanced warnings of breathing difficulty. .

Biomechanics at UNeMed
Technology under development at Dr. Nick Stergiou’s biomechanics facility at the University of Nebraska at Omaha.
• Chaotic Music for Exercise: Chaotic or fractal music is created by varying the length between beats using non-linear or chaotic algorithms. Dr. Stergiou’s laboratory published results showing that when patients performed physical activity in time with music that had the beats changed to become chaotic then those patients showed significant improvement in gait stability. UNeMed is currently seeking a partner to develop a chaotic music application for smartphones that utilizes Dr. Stergiou’s custom algorithms. The application will generate chaotic music, determine a user’s gait stability, and work to rehabilitate gait stability by prompting a user to move in time with the chaotic music.
• Gait Analysis for Fall Risk: Gait analysis is an established field for analyzing disorders in how patients walk. Gait has enormous potential as a diagnostic tool for neurodegenerative, cardiopulmonary and other disorders. Dr. Stergiou’s laboratory invented an ultra-lite, wireless gait analysis device and custom analytics to measure when gait biorhythms are pathologic. UNeMed seeks a partner willing to fund a study to test the gait analysis platform for fall detection in two settings: the fall clinic at a regional hospital and at the University of Nebraska Medical Center’s Gerontology department. The system will enable a hospital-based service that can objectively measure fall risk for any patient so that they are released to the appropriate level of care.
• Postural Stability for Concussion Recovery: Postural stability is the ubiquitous micro corrections healthy people make when the stand – minute changes in a person’s center of balance. Dr. Stergiou published results showing that biomechanical analysis of postural stability reliably detects when football players receive and recover from concussions. Postural stability shows further potential to develop additional products that analyze patients for traumatic brain injury or other neurocognitive diseases. UNeMed seeks a partner to stand up a stoftware as a service company to deliver analysis of postural stability in hospitals, sports clinics, as well as professional and amateur sports teams.

The future will be made possible by biomechanics. It is next big thing in medical diagnostics

Even the most elementary functions of your body involve the coordination of incredibly complex systems. Just walking and breathing combine a sophisticated control of muscles, nerves, circulation and other systems.

When one of those systems is in the early stage of disease, it effects biomechanics. Your gait, balance or breathing changes.

The effect is invisible without complex computer analysis, which makes biomechanics a big-data problem. The future is here due to the convergence of many technologies.

Improved sensors make it possible to accurately measure biomechanics using simple things like pedometers or cell phone cameras. More powerful computing makes it possible to analyze biomechanics with complex algorithms. The internet allows a remote sensor, like the accelerometer on your smartphone, to measure your walking and upload it to a remote server for sophisticated analysis.

Biomechanics can detect a disease in its earliest stages, before patients are otherwise symptomatic. It utilizes existing and inexpensive equipment off the shelf or already in your pocket. More than 100 peer reviewed studies have demonstrated biomechanical analysis can detect early stage diseases—neurodegenerative, cardiovascular, pulmonary and traumatic brain injury—and biomechanical analysis will become even more sensitive and specific.

Biomechanics is everything the healthcare system needs right now. A data center, connected to thousands of smartphones that measures steps, breaths and heartbeats looks for otherwise invisible changes in those biorhythms consistent with disease.

If those changes are present then the user receives a warning or his doctor receives an alert. Biomechanics allows for extreme early diagnosis or real-time improved monitoring of diseases.

Biomechanical analysis is 21st century healthcare: internet enabled and personalized for your smartphone. It diagnoses, stages and manages a variety of diseases inexpensively, accurately and using the existing infrastructure of the internet.

 

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Biomechanics is topic of Aug. 12 Omaha Science Café

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Will focus on how biomechanics can treat, prevent movement-related disorders

by Lisa Spellman, UNMC

OMAHA, Neb. (July 29, 2014)—Biomechanics and how it is used to improve clinical practice is the focus of the next Omaha Science Café at 7 p.m. Aug. 12 at the Slowdown, 729 N. 14th St.

Sara A. Myers, PhD, an assistant professor in the School of Health, Physical Education, and Recreation and assistant director of the Biomechanics Research Building at the University of Nebraska at Omaha, is the featured speaker.

The mission of the Biomechanics Research Building is to provide a new understanding of the dynamic aspects of human movement via multidisciplinary approaches.

Dr. Myers’ research focuses on improving quality of life in individuals with various movement disorders, such as older individuals and those with peripheral arterial disease.

She has received research funding from several foundations and societies, including a prestigious pre-doctoral fellowship from the National Institutes of Health and the Department of Veterans’ Affairs.

A native of Hampton, Neb., Dr. Myers currently resides in Omaha with her husband Matt and their three children.

Science Cafés involve a face-to-face conversation with a scientist about current science topics. They are open to everyone (21 and older), and take place in casual settings like pubs and coffeehouses. Each meeting is organized around an interesting topic of conversation. A scientist gives a brief presentation followed by a question and answer period.

Pizza will be provided by The Nebraska Coalition for Lifesaving Cures for the first 50 people. For more information about Science Cafes, go to www.unmc.edu/sciencecafe. Podcasts of previous Science Cafes also are available on the website or available for download on iTunes at here.

Through world-class research and patient care, UNMC generates breakthroughs that make life better for people throughout Nebraska and beyond. Its education programs train more health professionals than any other institution in the state. Learn more at unmc.edu and follow us on social media.

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UNMC researchers receive $10 million grant to study antibiotic resistance

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by Vicky Cerino, UNMC

OMAHA, Neb. (July 24, 2014)—Researchers at the University of Nebraska Medical Center have received a five-year grant for $10 million to continue work on a project to fight the growing threat of methicillin-resistant Staphylococcus aureus (MRSA).

MRSA, a bacterium resistant to many antibiotics, is a big problem in hospitals and can cause wound infections to more invasive diseases. In 2011, about 721,800 health-care associated infections occurred in 648,000 hospital patients, according to the U.S. Centers for Disease Control and Prevention. About 75,000 patients died during their hospitalizations.

Ken Bayles, PhD, principal investigator of the program project grant, said he and his team are working on four projects first funded in 2009 by the National Institutes of Health National Institute of Allergy and Infectious Diseases.

Projects will focus on biofilms produced by Staphylococcus aureus and understanding their role in causing infections of artificial devices. Biofilm is a natural biologic material that grows on surfaces — like the plaque on teeth before brushing.

“Biofilm can affect any manmade device that is implanted into our bodies,” Dr. Bayles said. “With more and more people getting implanted devices, including stents, pacemakers, catheters, orthopedic devices like knee and hip replacements, all are targets for staph infections.”

It is estimated that the rate of infection of implanted devices is between 1 and 5 percent. He said infections happen in medical devices usually through contamination of the surgical wound.

“Getting rid of biofilm associated with implanted devices is difficult because biofilm bacteria are resistant to the antibiotics used to treat infections,” Dr. Bayles said.

If antibiotics don’t work, the device will need to be removed, followed by extensive antibiotic treatment, and then replacement with a new device. It’s traumatic for the patient and adds a significant burden to health care costs, he said.

Three of the projects will be conducted at UNMC and include Dr. Bayles, Paul Fey, PhD, and Tammy Kielian, PhD The fourth project will be headed by Alex Horswill, PhD, at the University of Iowa.

Through world-class research and patient care, UNMC generates breakthroughs that make life better for people throughout Nebraska and beyond. Its education programs train more health professionals than any other institution in the state. Learn more at unmc.edu and follow us on social media.

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